Precocious puberty

Question 1

Define Precocious puberty

Answer 1

the onset of secondary sexual characteristics before:

• Girls: 8 years (breast development, pubic hair, or menarche).
• Boys: 9 years (testicular enlargement, pubic hair, or voice changes).

Question 2

Precocious puberty gold standard Mx

Answer 2

GnRH agonists (e.g., leuprolide)

Question 3

Urgent referral for precocious puberty

Answer 3

Boys <9 years with testicular enlargement.

Girls <8 years with breast development + rapid growth.

Neurological symptoms (e.g., headaches, vision changes)

Question 4

Lab findings for precocious pubrty

Answer 4

CPP: Elevated LH/FSH, advanced bone age.

PPP: Low LH/FSH with high sex steroids (testosterone/oestradiol)

Question 5

Prcocious puberty complications

Answer 5

• Short stature
• Early menarche
• increased risk breast, endometrial, testicular cancer (oestrogen exposure)