Wilm's Tumour

Question 1

Define Wilms’ Tumour

Nephroblastoma

Answer 1

the most common form of renal malignancy in childhood. It usually occurs in children under 5 years
Arising from nephroblast cells

Question 2

Wilms’ Tumour Sx

Answer 2

• Abdo pain
• Abdo distention
• HTN
  RED FLAGS
• unintenional WL
• Fever
• Haematuria
• Lethargy

Question 3

Wilms’ Tumour clinical presentations

Answer 3

• Unilateral painless, NT, firm, smooth abdo mass
• ballotable and does not move with respirations

Question 4

Wilms’ Tumour Risk factors

Answer 4

• Age <5 years
• Congenital urogenital anomalies (cryptorchidism etc.)
• L&raquo_space; R kidney (can be bilateral)

Question 5

Wilms’ Tumour Diagnostic Ix

Answer 5

1. Abdo USS w/doppler
2. CT CAP or MRI without contrast for staging
3. Bloods: U&E, LFTs, FBC, Bone profile
4. Bone scan (for bone met)

Question 6

Wilms’ Tumour definitive Dx Ix

Answer 6

Bx for histology of tumour

Question 7

Wilms’ Tumour Mx

Answer 7

• Nephrectomy followed by
  1. Adjuvant chemotherapy
  2. Adjuvant radiotherapy

Question 8

2ww referral criteria for Wilm’s tumour

Answer 8

• Abdo mass
• Haematuria (usu. microscopic)
• Organomeagly