Flashcards in Quiz 3: Alkaline Phosphatase Deck (3)
ALP functions in body, Isoenzyme/Isoform
Catalyzes the transphorylation of a wide variety of synthetic substrates (removes phosphate groups from ortho-phosphoric bonds).
Bone, liver, kidney, intestine and placenta major sources of ALP
Isoenzyme gene coded.
Isoform, altered form of enzyme due to posttranslational modification (glycation, siliac acid etc)
ALP Ranges, Interferences
RI for total: 30-90 IU/L serum
RI for bone fraction: 7 - 30 IU/L serum
Interferences: hemolysis (6xRBC), diet, and stability