Flashcards in Quiz 4: Albumin Deck (8)
• Migrates ahead of albumin in electrophoresis
• Transport protein for thyroid hormones and Vitamin A (retinol).
• Synthesized in liver and is a major indicator of nutritional status of the patient.
• Synthesized in the Liver
• Albumin is the most abundant protein in the body.
• Most but not all urine protein is albumin
• Measured by dye-binding methods (bromcresol green; bromcresol purple etc)
• 3.9 - 5.1 g/dL (almost 50% of the total protein in serum)
Functions of Albumin
• Control of colloid oncotic pressure (COP), the movement of water across membranes (high conc. of albumin maintains appropriate amount of fluid in tissues)
• Binding to substances in blood:
- carry hormones and drugs (bound vs. free)
- act as a buffer by binding free ions.
Increased Serum Albumin Levels
Found only in dehydration
Decreased Serum Albumin Levels
Found in a wide variety of conditions including:
(a) decreased synthesis in the liver
(b) hepatic disease (c) urinary loss
A/G Ratio Calculation and Ranges
• A measure of the ration between the two major forms of protein found in the serum, albumin and the globulins.
• Total Protein = Albumin + Globulins
• Total Protein - Albumin = Globulins
• TP = 6.4 - 8.3 g/dL
• Albumin = 3.9 - 5.1 g/dL