Rapid Review - Classic Labs / Findings (3) Flashcards Preview

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Flashcards in Rapid Review - Classic Labs / Findings (3) Deck (30):
1

“Lead pipe” appearance of colon on barium enema x-ray

Ulcerative colitis (loss of haustra)

2

Linear appearance of IgG deposition on glomerular basement membrane

Goodpasture syndrome

3

Low serum ceruloplasmin

Wilson disease (hepatolenticular degeneration)

4

“Lumpy bumpy” appearance of glomeruli on immunofluorescence

Poststreptococcal glomerulonephritis (immune complex deposition of IgG and C3b)

5

Lytic (“hole punched”) bone lesions on x-ray

Multiple myeloma

6

Mammary gland (“blue domed”) cyst

Fibrocystic change of the breast

7

Monoclonal antibody spike

- ƒƒMultiple myeloma (usually IgG or IgA)
- ƒƒMonoclonal gammopathy of undetermined significance (MGUS consequence of aging)
- ƒƒWaldenström (M protein = IgM) macroglobulinemia
-ƒƒ Primary amyloidosis

8

Mucin-filled cell with peripheral nucleus

“Signet ring” (gastric carcinoma)

9

Narrowing of bowel lumen on barium x-ray

“String sign” (Crohn disease)

10

Necrotizing vasculitis (lungs) and necrotizing glomerulonephritis

Granulomatosis with polyangiitis (Wegener; PR3-ANCA/ c-ANCA) and Goodpasture syndrome (anti–basement membrane antibodies)

11

Needle-shaped, negatively birefringent crystals

Gout (monosodium urate crystals)

12

Nodular hyaline deposits in glomeruli

Kimmelstiel-Wilson nodules (diabetic nephropathy)

13

Novobiocin response

Sensitive: Staphylococcus epidermidis; resistant: Staphylococcus saprophyticus

14

“Nutmeg” appearance of liver

Chronic passive congestion of liver due to right heart failure

15

“Onion skin” periosteal reaction

Ewing sarcoma (malignant round-cell tumor)

16

Optochin response

Sensitive: Streptococcus pneumoniae; resistant: viridans streptococci

17

Periosteum raised from bone, creating triangular area

Codman triangle on x-ray (osteosarcoma, Ewing sarcoma, pyogenic osteomyelitis)

18

Podocyte fusion or “effacement” on electron microscopy

Minimal change disease (child with nephrotic syndrome)

19

Polished, “ivory-like” appearance of bone at cartilage erosion

Eburnation (osteoarthritis resulting in bony sclerosis)

20

Protein aggregates in neurons from hyperphosphorylation of tau protein

Neurofibrillary tangles (Alzheimer disease) and Pick bodies (Pick disease)

21

Psammoma bodies

Meningiomas, papillary thyroid carcinoma, mesothelioma, papillary serous carcinoma of the endometrium and ovary

22

Pseudopalisading tumor cells on brain biopsy

Glioblastoma multiforme

23

RBC casts in urine

Acute glomerulonephritis

24

Rectangular, crystal-like, cytoplasmic inclusions in Leydig cells

Reinke crystals (Leydig cell tumor)

25

Renal epithelial casts in urine

Acute toxic/viral renal injury

26

Rhomboid crystals, positively birefringent

Pseudogout (calcium pyrophosphate dihydrate crystals

27

Rib notching

Coarctation of the aorta

28

Ring-enhancing brain lesion in AIDS

Toxoplasma gondii, CNS lymphoma

29

Sheets of medium-sized lymphoid cells with scattered pale, tingible body–laden macrophages (“starry sky” histology)

Burkitt lymphoma (t[8:14] c-myc activation, associated with EBV; “black sky” made up of malignant cells)

30

Silver-staining spherical aggregation of tau proteins in neurons

Pick bodies (Pick disease: progressive dementia, changes in personality)

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