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Flashcards in Renal Deck (92)
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1

Abs associated with Goodpastures? Where else can these Abs React on?
With what specific collagen?

Anti-GBM Abs- Cross react with BM of lung alveoli- Hemoptysis!

@ alpha 3 chain of Collaen Type IV-

2

GoodPastures Disease presents with what renal disease?
With what Immunoflorescent findings?
EM?

RPGN
IgG & C3 in Linear Deposits
GBM diruptions and fibrin deposition on EM

3

What stones can precipitate from ACIDIC urine?

Uric Acid, Cysteine, Calcium Oxalate stones

4

What stones can precipitate from ALKALINE urine?

struvite, Calcium PHOSPATE stones

5

What 2 things can dissipate Stones (specifically calcium precipitated stones)

Citrate (binds free Ca2+ => excretion)
High fluid intake

6

Oncotic Pressure is what?

How does it relate to Hyper/HypoProtein/Albuminemia

Pressure that keeps and fluid within the vessel/plasma.

Hyper= high oncotic pressure => plasma fluid retention due to high amount of albumin/protein in the blood

Hypo= low oncotic pressure => intersitial edema formation

7

MCC of ESRD in US? (renal disease)

best method for early detection?

Diabetic Nephropathy

Microalbuminuria detection

8

When does Autosomal Reessive Polycystic kidney disease usually present? and how

At birth/early childhood

enlarged kidneys with cysts >1cm visble on US

9

how long after vasectomy is sperm still viable?

3months
20 ejaculations

10

IV Acyclovir requires which co-administrative treatment and why?

aggressive IV hydration because crystalline nephropathy can occur

11

What type of endocrine disorder is caused by Chronic renal failure commonly?

hyperparathyrioidsm

Increase PTH
Decr. Calcitriol
Low Calcium
High Phosphate

12

What disease is an inborn defect of the transporter of cystine, ornithine, arginine & lysine? and when and which symptom is seen?

Cystinuria

renal colic @ 2-3rd decades of life

pathognomonic hexoganal cystine crystals

13

Where does ADH act?

Medullary segment of the collecting duct

14

Predisposers to post-streptococcal glomerulonephritis? hypersensitivity reaction type?

impetigo
cellulitis
pharyngitis
FROM STREP (GrpA B-hemolytic Strep)

TypeIII HSR

15

IL -2 actions? Which cancers can it effect and How?

Produced by Thelper => stimulates growth of CD4 & CD8 Tcells & BCells

activates NK cells & Monocytes

overall anti-cancer effect on metastatic melanoma & Renal Cell carcinoma

16

Fabry's disease (deficiency?)

early manisfestations?

without enzyme replacement what will this disease lead to?

alpha glalactosidase A deficiency (cant metabolize ceremide trihexoside)

hypohidrosis
acroparesthesia
angiokeratomas

renal failure

17

Amphotericin B main side effect?

Nephrotoxicity
Hypokalemia hypomagnesmia => increase distal tubular membrane permiabilityy

18

NSAIDs do what to prostaglandin synthesis

inhibit it

ibuprofen, naproxen, indomethacin

19

What effect do Loop dieuretics have on prostaglandins?

what will happen with concurrent use of NSAIDs

Stimulate prostaglandin release.=> increased GFR and enhanced drug delivery

decreased diuretic response

20

How does Vasopressing affect the V2 reeceptor?

v2 receptor-mediated increase in permeability to water and urea at the luminal membrane of the inner medullary collecting duct

21

Winters Formula
PaCO2=?

(1.5 X HCO3-) + 8+/-2

PaCO2 > # => concurrent respiratory acidosis
PaCO2 < # => concurrent respiratory alkalosis

Use to evaluate respiratory compensation when there is metabolic ACIDOSIS

22

Histology of postreptococcal glomerulonephritis (3)

Enlarged hypercellular glomeruli on light microscopy

Lumpy bumbpy granular deposits of igG and C3 on immunofluorescence.

Electron dense deposits on the epithelial side of basal membrane on e- microscopy

23

Which bugs lack:
peptidoglycan within cell wall
cell wall entirely

Rx?

Chlamydia Trachomatis
Ureaplasma urealyticum

Antiribosomal abx= Microlides/Tetracyclinnes

24

Which portion of Kidney system is involved in acute renal colic due to nephrolithiasis?

Calices/Ureters

25

Pts with sickle cell, DM , analgesic nephropathy, severe acute pyelonephritis can have which type of pathologic damage of the kidney?

Renal papillary necrosis

26

When and how does acute interstitial nephritis present?

Fever maculopapular rash and Acute renal failure sx,

1-3 wks post B-lactam ABx

27

Contraindications to OCP (oral contraceptive pills)

Hx of thromboemolic event/stroke
Hx of estrogen dependent tumor
>35 heavy smoker
hypertriglyceridemia
active liver disease
pregnancy

28

What happens to Creatinine as GFR decreases?

Increases?

Creatinine increase (when GFR halves-Creatinine doubles)

small increase in creatinine

29

Standard treatment of dysuria and/or urethral discharge in young adult?

ceftriaxone
AZITHROMYCIN/Doxycycline

30

Flucanozole is used to treat?

candidiasis
cryptococcosis
histoplasmosis
blastomycosis
coccidiodomycosis