Flashcards in Renal Deck (92)
Abs associated with Goodpastures? Where else can these Abs React on?
With what specific collagen?
Anti-GBM Abs- Cross react with BM of lung alveoli- Hemoptysis!
@ alpha 3 chain of Collaen Type IV-
GoodPastures Disease presents with what renal disease?
With what Immunoflorescent findings?
IgG & C3 in Linear Deposits
GBM diruptions and fibrin deposition on EM
What stones can precipitate from ACIDIC urine?
Uric Acid, Cysteine, Calcium Oxalate stones
What stones can precipitate from ALKALINE urine?
struvite, Calcium PHOSPATE stones
What 2 things can dissipate Stones (specifically calcium precipitated stones)
Citrate (binds free Ca2+ => excretion)
High fluid intake
Oncotic Pressure is what?
How does it relate to Hyper/HypoProtein/Albuminemia
Pressure that keeps and fluid within the vessel/plasma.
Hyper= high oncotic pressure => plasma fluid retention due to high amount of albumin/protein in the blood
Hypo= low oncotic pressure => intersitial edema formation
MCC of ESRD in US? (renal disease)
best method for early detection?
When does Autosomal Reessive Polycystic kidney disease usually present? and how
At birth/early childhood
enlarged kidneys with cysts >1cm visble on US
how long after vasectomy is sperm still viable?
IV Acyclovir requires which co-administrative treatment and why?
aggressive IV hydration because crystalline nephropathy can occur
What type of endocrine disorder is caused by Chronic renal failure commonly?
What disease is an inborn defect of the transporter of cystine, ornithine, arginine & lysine? and when and which symptom is seen?
renal colic @ 2-3rd decades of life
pathognomonic hexoganal cystine crystals
Where does ADH act?
Medullary segment of the collecting duct
Predisposers to post-streptococcal glomerulonephritis? hypersensitivity reaction type?
FROM STREP (GrpA B-hemolytic Strep)
IL -2 actions? Which cancers can it effect and How?
Produced by Thelper => stimulates growth of CD4 & CD8 Tcells & BCells
activates NK cells & Monocytes
overall anti-cancer effect on metastatic melanoma & Renal Cell carcinoma
Fabry's disease (deficiency?)
without enzyme replacement what will this disease lead to?
alpha glalactosidase A deficiency (cant metabolize ceremide trihexoside)
Amphotericin B main side effect?
Hypokalemia hypomagnesmia => increase distal tubular membrane permiabilityy
NSAIDs do what to prostaglandin synthesis
ibuprofen, naproxen, indomethacin
What effect do Loop dieuretics have on prostaglandins?
what will happen with concurrent use of NSAIDs
Stimulate prostaglandin release.=> increased GFR and enhanced drug delivery
decreased diuretic response
How does Vasopressing affect the V2 reeceptor?
v2 receptor-mediated increase in permeability to water and urea at the luminal membrane of the inner medullary collecting duct
(1.5 X HCO3-) + 8+/-2
PaCO2 > # => concurrent respiratory acidosis
PaCO2 < # => concurrent respiratory alkalosis
Use to evaluate respiratory compensation when there is metabolic ACIDOSIS
Histology of postreptococcal glomerulonephritis (3)
Enlarged hypercellular glomeruli on light microscopy
Lumpy bumbpy granular deposits of igG and C3 on immunofluorescence.
Electron dense deposits on the epithelial side of basal membrane on e- microscopy
Which bugs lack:
peptidoglycan within cell wall
cell wall entirely
Antiribosomal abx= Microlides/Tetracyclinnes
Which portion of Kidney system is involved in acute renal colic due to nephrolithiasis?
Pts with sickle cell, DM , analgesic nephropathy, severe acute pyelonephritis can have which type of pathologic damage of the kidney?
Renal papillary necrosis
When and how does acute interstitial nephritis present?
Fever maculopapular rash and Acute renal failure sx,
1-3 wks post B-lactam ABx
Contraindications to OCP (oral contraceptive pills)
Hx of thromboemolic event/stroke
Hx of estrogen dependent tumor
>35 heavy smoker
active liver disease
What happens to Creatinine as GFR decreases?
Creatinine increase (when GFR halves-Creatinine doubles)
small increase in creatinine
Standard treatment of dysuria and/or urethral discharge in young adult?