Flashcards in Renal and Endocrine cases Deck (13):
What happens to ACTH produced by the pituitary in the presence of dexamethasone? What about an ectopic ACTH production?
Reduce if pituitary, no ACTH reduction if ectopic
What would happen to ACTH if the MC2R receptor did not function?
Higher, because there is no cort synthesis
What is the MOA of amenorrhea with cushings?
Cort inhibits CRH production in the hypotahlamus
What happens to insulin sensitivity in Cushing's?
Decreases due to chronic elevated BG levels
What is the effect of Cort on aldosterone?
Increases d/t enzyme saturation of 11beta-HSD2
How does Cushing's cause HTN?
Why osteoporosis with Cushings?
Cort inhibits osteoblasts
What is the main control of prolactin?
Dopamine (inhibits it)
What are the two major chemicals that the prostate releases into the ejaculatory duct?
What are the two major chemicals that the seminal vesicles release into the ejaculatory duct?
Fibrinogen and fructose
What does inhibin B repress in the male?
What is the other name for thyroxine-binding prealbumin?