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Flashcards in Respiratory diseases of pigs Deck (85)
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61

What is the gross pathology of swine influenza?

1. conjunctivitis and nasal discharge
2. consolidation of cranial and middle lobes
3. enlarged and edematous bronchial/mediastinal LN
4. blood tinged fibrinous exudate
5. interlobular edema
6. gross lesions similar to mycoplasma hyopneumoniae

62

What is the distribution of swine influenza in lung pathology?

anteroventral
consolidation
checkerboard appaerance

63

What is the histopathology of swine influenza?

necrotizing bronchitis/bronchiolitis
airways/alveoli filled with exudate
bronchointerstitial pneumonia

64

How is swine influenza diagnosed?

1. histopathology (necrotizing bronchiolitis and bronchitis)
2. confirmation via PCR, IHC

65

Why might a false negative occur with swine influenza?

lesions come and go very quickly
may get false negative >8 days post infection

66

What kind of antibody is used with SIV IHC?

type A antibody
works in all species

67

How is diagnosis of SIV done on a population level?

1. serology--serotypes specific or generic
2. PCR--nasal swabs
3. genomic analysis

68

When is the best time to collect a sample for SIV?

48 hr post exposure (24hr of showing signs)

69

What are 4 aspects of treatment and control of SIV?

1. anti-inflammatories
2. antimicrobials (2ndry infection)
3. improve indoor air quality
4. vaccination--commercial vs autogenous

70

What are the most virulent serotypes of actinobacillus pleuropneumoniae?

1
5
7

71

What is the epidemiology of actinobacillus pleuropneumoniae?

1. primarily horizontal transmission
2. not likely to transmit between herds
3. short incubation periods (6-12hrs)

72

Which resp disease is likely to transmit between herds in hog dense areas: SIV or actinobacillus pleuropneumoniae?

SIV

73

Severity of actinobacillus pleuropneumoniae depends on what?

1. serotype
2. exposure dose
3. immune status of herd
4. concurrent dz

74

Which resp disease has an incubation period of 6-12hrs?

actinobacillus pleuropneumoniae

75

What is the pathogenesis of actinobacillus pleuropneumoniae?

1. colonize tonsils, alveolar epithelium
2. phagocytosed by macrophages
3. produce 4RTX exotoxins
4. inflammatory cytokine production
5. septic shock
6. arteriolar thrombosis and alveolar necrosis

76

What exotoxins does actinobacillus pleurpneumoniae produce?

4 RTX exotoxins (Apo I, II, III, IV)

77

What do the exotoxins and the cytokines involved in actinobacillus pleuropneumoniae infection cause?

1. septic shock (peracute death)
2. arteriolar thrombosis and alveolar necrosis

78

What are the clinical signs of actinobacillus pleuropneumoniae?

1. peracute: cyanosis, foamy bloody nasal discharge, found dead
2. acute: dyspnea, coughing, agonal breathing
3. chronic: chronic pleuritis-->chronic cough; reduced appetite/growth

79

What is the pathology of peracute and acute actinobacillus pleuropneumoniae?

necrotizing and hemorrhagic pneumoniae
well demarcated, usually CAUDAL LOBES
focal pleuritis

80

What is the pathology of chronic actinobacillus pleuropneumoniae

1. chronic pleuritis and adhesions
2. consolidation and necrosis
3. pulmonary abscesses

81

Why is pleuritis an important feature to look for when looking for actinobacillus pleuropneumoniae

because carcasses going through a scalding tank can look like they have hemorrhagic pneumoniae but they wont have pleuritis

82

How is actinobacillus pleuropneumoniae diagnosed at the individual level?

1. necrotizing hemorrhagic pneumoniae with focal pleuritis
2. culture and serology

83

What types of serology is there for actinobacillus pleuropneumoniae?

1. generic ELISA
2. specific for individual serotype
(remember some cross react)

84

How is actinobacillus pleuropneumoniae controlled?

1. environmental control
2. strategic medication
3. vaccination (serotype specific, autogenous)

85

Does actinobacillus pleuropneumoniae vaccine protect against infection? are they used much in canada?

no and no