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Microbiology > RNA Viruses > Flashcards

RNA Viruses Flashcards

1
Q

HIV I/II mode of action

A

Encode reverse transcriptase enzyme which makes a double stranded DNA from the single stranded RNA genome

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2
Q

HIV I groups

A

M, N, o

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3
Q

HIV II groups

A

A1 and A2

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4
Q

HIV tropism to human cells

A

CD4+ cells — T helper cells, macrophages, dendritic cells, astrocytes

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5
Q

Stages of HIV Replication/Pathology

A
  1. Binding
  2. Fusion
  3. Reverse transcription
  4. Integration
  5. Replication
  6. Assembly
  7. Budding
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6
Q

HIV I/II

A

Retroviridae

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7
Q

HTLV I/II

A

Retroviridae

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8
Q

Lymphocytic choriomeningitis virus (LCM/LCMV)

A

Arenaviridae

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9
Q

Lassa fever

A

Arenaviridae

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10
Q

Rift Valley fever

A

Bunyaviridae

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11
Q

Crimean Congo hemorrhagic fever

A

Bunyaviridae

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12
Q

California encephalitis virus

A

Bunyaviridae

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13
Q

Sin nombre

A

Bunyaviridae

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14
Q

Hantaa and Seoul virus

A

Bunyaviridae

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15
Q

Hepatitis D virus

A

Deltaviridae

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16
Q

Marburg virus

A

Filoviridae

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17
Q

Ebola virus

A

Filoviridae

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18
Q

Influenza

A

Orthomyxoviridae

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19
Q

Parainfluenza 1-4

A

Paramyxoviridae

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20
Q

Mumps virus

A

Paramyxoviridae

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21
Q

Measles (Rubeola) virus

A

Paramyxoviridae

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22
Q

Respiratory syncytial virus

A

Paramyxoviridae

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23
Q

Rabies virus

A

Rhabdoviridae

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24
Q

SARS-CoV

A

Coronaviridae

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25
Q

MERS-CoV

A

Coronaviridae

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26
Q

Yellow fever

A

Flaviviridae

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27
Q

Japanese encephalitis

A

Flaviviridae

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28
Q

West Nile virus

A

Flaviviridae

29
Q

Dengue and Zika virus

A

Flaviviridae

30
Q

Hepatitis C

A

Flaviviridae

31
Q

Hepatitis E

A

Flaviviridae

32
Q

Eastern equine encephalitis

A

Togaviridae

33
Q

Chikungunya

A

Togaviridae

34
Q

Rubella

A

Togaviridae

35
Q

Norwalk virus

A

Calciviridae

36
Q

Enterovirus

A

Picornaviridae

37
Q

Poliovirus

A

Picornaviridae

38
Q

Hepatitis A virus

A

Picornaviridae

39
Q

Rhinovirus

A

Picornaviridae

40
Q

Rotavirus

A

Reoviridae

41
Q

Colorado tick fever virus

A

Reoviridae

42
Q

LCM/LCMV transmission

A

Aseptic meningitis by inhalation of rodent urine or infected cultures
<1% mortality

43
Q

Lassa fever transmission

A

Person to person exposure to infected body fluids

5% mortality

44
Q

Rift Valley/Crimean Congo/California encephalitis transmission

A

Infected mosquito

Neurological disease

45
Q

Hepatitis D role

A

Incomplete virus, require other virus as a helper to replicate
Enveloped, helical nucleocapsid
Blood or body exposure to mucous membranes
NO vaccine

46
Q

Marburg info

A

Mortality 20-90%
Incubation 5-10 days
Exposure to contaminated body fluids

47
Q

Ebola info

A

Mortality 70-90%
Incubation 8-10 days
Exposure to contaminated body fluids

48
Q

Ebola treatment

A

Adoptive serum transfer, experimental drug ZMapp

49
Q

Influenza A

A

80% all infections
Pandemics and epidemics
Humans, avian, swine

50
Q

Influenza B

A

20% all infections

Human infection only

51
Q

Influenza C

A

Rare, human infection only

52
Q

Influenza Peplomers

A

Hemagglutinin and Neuraminidase

53
Q

Antigenic drift

A

Very small changes occur in the virus RNA over time, these changes make the H and N protein different

54
Q

Antigenic shift

A

2 different viruses infected the same cell. As new viral particles are made they contain a mix of both viruses

55
Q

Measles info

A

Infects epithelium of respiratory tract and spread by coughing or sneezing

56
Q

Measles symptoms

A

2-3 days koplik spots, 3-5 days red raised rash (extanthem) starting at hair lines spreads down throughout body

57
Q

Respiratory syncytial virus info

A

Most common cause of respiratory disease < 1 yr olds

Most common in winter months

58
Q

RSV treatment

A

Synagis a monoclonal antibody that blocks attachment

59
Q

Rabies clinical phases

A

Prodromal
Furious
Dumb
Coma

60
Q

Rabies transmission

A

Exposure to infected saliva secretion by bites, inoculation of mucous membranes, rare case transplantation

61
Q

Rabies viral entry

A

Nerve endings, advances to ganglia, spinal cord and brain

62
Q

Rabies treatment

A

Infuse HRIG, vaccination

63
Q

Norwalk virus transmission

A

Fecal oral contamination
Highly contagious
#1 associated food borne illness
10-20 virus particles infectious dose

64
Q

Poliovirus symptoms

A

Targets brain and spinal cord

70% asymptomatic, 25% flu like for 2-5 days then resolve

65
Q

Post polio syndrome

A

Progressive muscle deterioration occurs in 25-50% of patients infected during childhood

66
Q

Hepatitis A treatment

A

Vaccination recommended person 1yrs old and older at high risk
Pre and post exposure immunoglobulin therapy

67
Q

Echovirus

A

Similar to polio but less virulent

Responsible for respiratory infections, conjunctivitis, hand foot mouth disease

68
Q

Rhinovirus info

A

Likes to replicate in cooler temp (32C)

Microbiology (37 decks)

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