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Flashcards in Secondary Hemostasis Deck (35)
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What does vitamin K deficiency result in?

disrupts function of multiple coag factors

vit K is essential for gamma carboxylating factors


How does coumadin work?

blockes epoxide reductase


Who is prone to vitamin K deficiency?

1) newborns
2) long term antibiotic therapy
3) malabsorption


What are 3 reasons why liver failure can lead to bleeding problems?

1) decreased production of coag factors
2) decreased activation of vitamin K by epoxide reductase


Why can large volume transfusions lead to bleeding problems?

dilutes coag factors (relative deficiency)