SEPSIS Flashcards
(28 cards)
A clinical syndrome that complicates
severe infection and is characterized
by the systemic inflammatory
response syndrome (SIRS), immune
dysregulation, microcirculatory
derangements, and end-organ
dysfunction
sepsis
Displays cardinal signs of
inflammation, vasodilation, increased
microvascular permeability, and
leukocyte accumulation
sepsis
what is SIRS
systemic inflammatory response syndrome
Diminished non-specific (___) &
specific (___) immunity
inflammatory
humoral
antibodies absent in sepsis
IgA and IgM
true or false - sepsis can be acquired prenatally across the placenta
true
- an infection in the blood that spreads throughout the body & occurs in a neonate
- most common in preterm infant or the infant born after a difficult or traumatic labor & delivery
sepsis neonatorum
neonatal septicemia
neonatal sepsis
- Acquired in the perinatal period
- Onset most often appears in the 1st 24
hrs. of life
early onset sepsis
- Acquired after delivery
- Infection occurs 1-3 weeks after birth
late onset sepsis
- (+) blood culture in an infant who is less
than 72 hrs of age - (< 3 days after birth)
early onset sepsis
most common organism associated with EOS
e. coli in the vagina
- Primarily nosocomial (health care-associated infection)
- Offending organisms usually are: staphylococci, Klebsiella
organisms, enterococci, E. coli, & Pseudomonas or Candida
species
late onset sepsis
Postnatal infection is acquired by ___ from
other infants, personnel, or objects in the environment
cross-contamination
Bacteria such as Klebsiella & Pseudomonas commonly called
“___” are found in water supplies; humidifying
apparatus; sink drains; suction machines; moist respiratory
equipment; contaminated hospital equipment & indwelling
venous & arterial catheters used for infusions, blood
sampling & monitoring VS
water bugs
sepsis risk factors
- PROM
- Fetal distress
- Maternal infection
- Multiple obstetric procedures
- Prematurity
- Congenital anomalies
- Invasive procedures
- Acquired injuries
- Nosocomial exposure to NICU
after microorganisms invade body tissues, the immune response provokes the activation of ___
biochemical cytokine and mediators
Increased ___ & vasodilation interrupt the body’s ability to
provide adequate perfusion, O2, & nutrients to the tissues & cells.
capillary permeability
Proinflammatory & anti-inflammatory cytokines released during the inflammatory response & activates the ___ that forms clots
whether or not there is bleeding
coagulation system
stages of sepsis:
a suspected or proven invasion caused by any pathogen or a clinical syndrome associated with a high probability of infection
infection
stages of sepsis:
SIRS in the presence of infection
sepsis
stages of sepsis:
sepsis plus one of the ff:
- cardiovascular dysfunction
- ARDS
- 2 or more organ dysfunctions
severe sepsis
stages of sepsis:
sepsis and cardiovascular organ dysfunction
severe shock
occurs when the body’s inflammatory state
is revved up in response to an insult
Systemic Inflammatory Response
Syndrome
s/sx of SIRS in children
T =
HR =
RR =
WBC =
PCO2 =
T = > 38.5 or < 36
HR = > 90
RR = > 20
WBC = > 12,000 or < 4000 or > 10% bands
PCO2 = < 32 mmHg
