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Anatomic pathology > Skin > Flashcards

Flashcards in Skin Deck (352)
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300

Epithelioid angiosarcoma vs. epithelioid hemangioma.

Epithelioid hemangioma:

− Symmetrical.
− No nuclear atypia.

301

Angiosarcoma: Immunohistochemistry (4).

CD31, CD34, ERG.

Lymphatic tumors: D2-40.

302

Angiosarcoma: Electron microscopy.

Weibel-Palade bodies (rod-shaped; resemble lysosomes).

303

Dabska tumor.

Malignant intravascular papillary angioendothelioma.

304

Angioleiomyoma: Anatomic site.

Extremities, esp. lower extremities.

305

Dartoic leiomyoma:

A. Anatomic sites.
B. Clinical presentation.

A. Scrotum, labium majus, areola.

B. Painless (unlike other leiomyomas).

306

Cutaneous leiomyosarcoma:

A. Age group.
B. Anatomic sites.

A. Second and third decades.

B. No anatomic predilection.

307

Cutaneous leiomyosarcoma:

A. Histologic architecture.
B. Metastasis.

A. Asymmetrical; forms fascicles; intermixed zones of hypercellularity and of better differentiation.

B. Hematogenous.

308

Keloid: Change in histology with age.

Early lesions: More vascular.

Older lesions: More fibrous.

309

Keloid vs. hypertrophic scar.

Hypertrophic scar:

− Limited to area of injury.
− Less myxoid matrix.

310

Dermatofibrosoma: Clinical sign.

Fitzpatrick's sign: Pinching the lesion results in a dimple.

311

Dermatofibroma: Aneurysmal variant.

Vascular proliferation and hemosiderin.

312

Dermatofibroma: Cellular type.

Densely cellular; increased mitotic figures.

313

Dermatofibroma: Immunohistochemistry.

Positive: Factor XIIIa.

Negative: CD34 (except at periphery of cellular DF).

314

Dermatofibrosarcoma protuberans: Change in clinical appearance with age.

Early: Tan or brown nodule, slow-growing.

Later: Blue-red, multilobular nodule, rapidly growing.

315

Dermatofibrosarcoma protuberans:

A. Overlying epidermis.
B. Invasion of fat.
C. Cytological atypia and mitosis.

A. Atrophic.

B. Replacement or lacelike infiltration.

C. Present but not prominent.

316

Dermatofibrosarcoma protuberans: Translocation.

t(17;22) :: COL1A1−PDGFB.

317

Dermatofibrosarcoma protuberans: Variant.

Bednar tumor contains pigmented spindle cells.

318

Neurofibroma: Preferred anatomic sites (2).

Palms, soles.

319

Neurofibroma: Cellular components.

Schwann cells.

Fibroblasts.

(Mast cells in the background.)

320

Schwannoma: Zones of Antoni.

Antoni A: Hypercellular.

Antoni B: Hypocellular; mucinous background.

321

Dermatofibroma vs. neurofibroma: Overlying epidermis.

DF: Hyperplastic, with pigmented basal cells.

NF: Atrophic, with indistinct rete ridges.

322

Merkel-cell carcinoma: Anatomic sites.

Head.

Extremities.

323

Merkel-cell carcinoma: Associated epithelial malignancy.

Squamous-cell carcinoma.

324

Merkel-cell carcinoma: Cytokeratin stain.

Positive for CK20.

325

Merkel-cell carcinoma: Electron microscopy.

Membrane-bound dense granules; perinuclear bundles or whorls of intermediate filaments.

326

Merkel-cell carcinoma: Divergent differentiation (3).

Squamous.

Adnexal.

Melanocytic.

327

Urticaria pigmentosa: Four forms.

Arising in infancy or childhood without systemic lesions.

Arising in adolescence or adulthood without systemic lesions.

Systemic mast-cell disease.

Mast-cell leukemia.

328

Urticaria pigmentosa: Age group in which ___ lesions appear.

A. solitary
B. diffuse erythrodermic
C. telangiectasia macularis eruptiva perstans

A, B. Infants.
C. Adults.

329

Urticaria pigmentosa: Age group in which ___ lesions appear.

A. maculopapular
B. nodular and plaquelike

Both: Infants and adults.