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Anatomic pathology > Skin > Flashcards

Flashcards in Skin Deck (352)
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330

Urticaria pigmentosa: Arrangement of mast cells in ___ lesions.

A. nodular and plaquelike
B. maculopapular and TMEP
C. erythrodermic

A. Throughout the dermis.

B. Around upper dermal blood vessels.

C. In a dense band in the upper dermis.

331

Urticaria pigmentosa: Location of split in the bullous type.

Subepidermal.

332

Urticaria pigmentosa: Stains for mast cells (5).

Giemsa, toluidine blue, Leder's.

CD117, tryptase.

333

Systemic mast-cell disease: Affected organs (6).

Bones.

Lymph nodes, spleen.

Liver.

Gastrointestinal tract.

Central nervous system.

334

Letterer-Siwe disease:

A. Age group.
B. Clinical presentation.
C. Locations of skin lesions.

A. 3 months to 3 years.

B. Constitutional symptoms, extraosseous lesions.

C. Scalp, face, mouth, neck, trunk.

335

Hand-Schüller-Christian disease:

A. Age group.
B. Clinical presentation.
C. Classic triad.

A. 2-6 years.

B. Otitis media plus all or part of the classic triad.

C. Defects in cranial bones, exophthalmos, diabetes insipidus.

336

Hand-Schüller-Christian disease: Locations of skin lesions (3).

Chest, axillae, groin.

337

Eosinophilic granuloma:

A. Age group.
B. Locations of internal lesions.
C. Locations of skin lesions.

A. 2-5 years.

B. Bones, lungs.

C. Scalp, face, mouth, groin.

338

Langerhans'-cell histiocytosis: Arrangement of Langerhans' cells.

Throughout the dermis and often in the epidermis.

339

Langerhans'-cell histiocytosis:

A. Immunohistochemistry.
B. Electron microscopy.

A. Positive: S100, CD1a, langerin.

B. Birbeck granules within Langerhans' cells.

340

Langerhans'-cell histiocytosis: Possible genetic defect.

Activating mutation of BRAF.

341

Congenital self-healing reticulohistiocytosis: Clinical course.

Appears at birth or shortly thereafter.

Involution begins at 2-3 months.

Gone within 1 year.

342

Mycosis fungoides, patch stage: Histology.

Lymphocytes form a patchy infiltrate in a papillary dermis with thickened collagen bundles.

Lymphocytes form small collections within a minimally spongiotic epidermis.

There may be psoriasiform hyperplasia.

343

Mycosis fungoides, plaque stage: Histology.

Similar to that of patch stage, but with denser and more bandlike infiltrate.

344

Mycosis fungoides, tumor stage: Histology.

Atypical lymphocytes form diffuse infiltrate.

There are more medium and large lymphoid cells.

345

Mycosis fungoides: Large-cell transformation.

More than 25% of tumor cells are large cells, or there are discrete nodules of large cells.

346

Mycosis fungoides: Immunophenotype (4).

Positive: CD3, CD4, CD5.

Negative: CD8 (except in younger patients).

CD7 is diminished or lost.

CD30 is positive in large-cell transformation.

347

Mycosis fungoides: Sézary's syndrome.

Erythrodermic mycosis fungoides + circulating tumor cells.

348

Mycosis fungoides: Related skin lesion.

Follicular mucinosis.

349

Cutaneous anaplastic large-cell lymphoma: Epidermal change.

Ulceration.

350

Cutaneous anaplastic large-cell lymphoma vs. lymphomatoid papulosis.

LP: Mixed infiltrate; fewer atypical lymphocytes.

351

CD30-positive lymphomas of the skin (3).

Anaplastic large-cell lymphoma.

Mycosis fungoides, late stage.

Pleomorphic T-cell lymphoma.