Flashcards in Skin Deck (352)
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120
Blastomycosis: Histology of spores (3).
8-15 μm, thick-walled, broad-based budding.
121
Paracoccidiomycosis: Histology of spores (2).
6-20 μm, narrow-based budding.
122
Chromoblastomycosis: Histology of spores (3).
6-12 μm, thick-walled, dark-brown and in clusters ("copper pennies").
123
Cryptococcus: Histology of spores.
2-4 μm (4-12 μm with capsule), narrow-based budding.
124
Histoplasmosis: Histology of spores.
2-4 μm, clear halo.
125
Sporotrichosis: Histology of spores.
4-6 μm, round or oval.
126
Pseudoepitheliomatous hyperplasia with suppurative and granulomatous inflammation: Differential diagnosis (3).
Deep mycoses.
Atypical mycobacterial infections.
Halogenodermas.
127
Cryptococcus: Alternative histology.
Xanthomatous infiltrate, especially in the immunocompromised.
128
Tuberculoid leprosy: Appearance of granulomas.
Elongated, surrounded by lymphocytes, arranged along neurovascular bundles.
129
Cutaneous leishmaniasis: Causes (3).
Old World: L. tropica.
New World: L. brasiliensis, L. mexicana.
130
Cutaneous leishmaniasis: Detection of parasites in a biopsy (2).
More likely to be seen in early lesions.
Giemsa stain can help.
131
Cutaneous leishmaniasis: Histology of late lesion.
Tuberculoid granulomas and lymphocytes.
Parasites may be undetectable.
132
Rhinoscleroma: Classic cell.
Mikulicz cell: Large histiocyte.
133
Granuloma inguinale:
A. Cause.
B. Inflammatory infiltrate.
C. Classic histologic finding.
A. Calymmatobacterium granulomatis.
B. Histiocytes and neutrophils.
C. Donovan body: Encapsulated, round to oval, 2-3 μm.
134
Leukocytoclastic vasculitis: Typically affected vessel in the skin.
Superficial dermal postcapillary venule.
135
Leukocytoclastic vasculitis: Bacterial cause.
Neisseria meningitidis.
136
Leukocytoclastic vasculitis: Immunofluorescence (2).
Most cases: IgM, C3, and fibrinogen around dermal vessels.
Henoch-Schönlein purpura: IgA.
137
Leukocytoclastic vasculitis: Chronic forms (2).
Erythema elevatum diutinum.
Granuloma faciale.
138
Livedo vasculitis: Anatomic location.
Lower legs.
139
Livedo vasculitis: Histology.
Fibrinoid matter in vessel walls leads to occlusion and ulceration.
Usually little inflammation.
140
Septic vasculitis: Histology.
Thrombi accompany leukocytoclastic vasculitis.
There may be intraepidermal pustules.
141
Causes of noninflammatory vasculitis of small vessels with deposits of pink matter in and around vascular lumens (4).
Monoclonal cryoglobulinemia.
TTP.
Warfarin- or heparin-induced vasculitis.
142
Superficial migratory thrombophlebitis: Associations (3).
Malignancy.
Hypercoagulable states.
Behçet's disease.
143
Superficial migratory thrombophlebitis: Typically affected vessel.
Small or medium-sized vein in deep dermis or subcutis of lower extremity.
144
Superficial migratory thrombophlebitis: Histology (3).
Occluding thrombus.
Neutrophils, lymphocytes, and histiocytes infiltrate muscle of vein.
Recanalization and resorption of thrombus occur with granulomatous reaction.
145
Superficial migratory thrombophlebitis: Histologic distinction from nodular vasculitis.
Nodular vasculitis affects arteries as well as veins.
146
Subcorneal pustular dermatosis: Clinical appearance.
Sterile pustules involving flexural surfaces and axillary and inguinal folds.
Groups of pustules may assume annular or serpiginous patterns.
147
Subcorneal pustular dermatosis: Histology (2).
Neutrophils beneath the stratum corneum and around superficial vessels.
Mild acantholysis may occur.
148
Subcorneal pustular dermatosis: Helpful ancillary tests.
Gram stain to exclude bullous impetigo.
Immunofluorescence to exclude autoimmune bullous diseases.
149
