Skin Flashcards

(28 cards)

1
Q

Name the three layers of the skin

A

epidermis
dermis
hypodermis

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2
Q

what is hypodermis made of? what is its function?

A

adipose tissue and loose connective tissue
energy
insulation
shock absorber
make hormones such as leptin
connect skin to underlying muscle and bone

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3
Q

What layers are in the dermis? What is its function?

A

top- papillary dermis
reticular dermis
dermal papillae
contains structures such as hairs, sweat glands, sensory structures

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4
Q

Name the layers of the epidermis top to bottom

A

s. corneum
s. lucidum (palms + soles of feet only)
S. granuloseum
s. spinosum
s. basale

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5
Q

What are the epithelial cells of the epidermis held by?

A

adherens

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6
Q

What is the S. corneum made of/ function?

A

squames (dead keratinocytes)
prone to injury
continuously shed

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7
Q

What is the S. lucidum made of/ function?

A

very thin palms and soles only

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8
Q

What is the S. granulosum made of/ function?

A

stratified squamous epithelium
lamellar granules
tonofibrils

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9
Q

What is the S. spinosum made of/ function?

A

cuboidal epithelial cells held together by desmosomes
produce lamellar bodies
golgi apparatus first appears

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10
Q

What is the S. basale made of/ function?

A

tall columnar

cell division cells differentiate and migrate + differentiate to keratinocytes

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11
Q

What is the normal transit time of a keratinocyte from basale to corneum? what happens in psoriasis ? what is it called when too much keratin produced?

A

28-40 days
time reduced in psoriasis to silvery scales
corneum replaced every 2-3 days
hyperkeratosis

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12
Q

Name three other cells in the epidermis and their function

A

melanocytes- produce melanin (pigment)
langerhans cells- specialised antigen presenting cell to mediate immune reponse
merkel- mechanoreceptors

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13
Q

Name the four types of skin. what is the generalisation often made?

A
hair 
non-hairy 
thin 
thick
hairy often thin 
non-hairy often thick
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14
Q

Describe the differences between hairy (thin) and non-hairy (thick) skin

A

thick (non-hairy):
no hair follicles/ sebaceous glands/ arrector pilli muscles
s. corneum thicker and dermis thinner
increase no mechanoreceptors
found palms/ soles/ between fingers and toes
ridges and furrowsregualr dermal papillae
s lucidum seen

thin (hairy):
hair follicles/ sebaceous glands/ arrector pilli muscles present 
smaller ridges and furrows
irregular dermal papillae
s. lucidum absent
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15
Q

What are skin appendages? name a few.

A
skin associated structures that serve a particular function 
hairs 
arrector pili muscles 
sebaceous glands 
sweat glands 
nails
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16
Q

Name the three types of hair and when they are found.

A

lanugo- fetus
vellus- replaces lanugo
terminal - head scalp etc due to testosterone

17
Q

what are the main functions of hair?

A

thermoregulation
sexual attraction
sensation
protection

18
Q

What are arrector pilli muscles?

A

SM fibers attached to papillary region of dermis (origin) and hair bulb (insertion)
contraction causes goose bumps

19
Q

What are nails made of and what are their function?

A

alpha keratin
protect
help with sensitivity and pressure

20
Q

What do free nerve endings detect?

21
Q

what do tactile discs detect?

A

touch pressure texture

22
Q

what do meissner corpuscles detect?

A

tapping and flickering movements

23
Q

what do pacinian corpuscle detect

24
Q

what do ruffini corpuscle detect

A

joint movement and tissue stretch

25
what does the root hair plexus detect?
vibrations in hair shaft
26
what do end bulbs detect?
thermoreceptors
27
Name the main signs of inflammation. What are they caused by?
``` rubor ( redness) tumor (swelling) calor ( heat) dolor (pain) functio laesa (loss of function) pruritus (itching) ``` caused by vasodilation increased microvasculature permeability influx of leukocytes
28
What is TEM?
toxic epidermal neurolysis | severe muco-cutaneous drug reaction