u/a Flashcards

1
Q

what happens to LV compliance, Angio II, Cardiac myosin heavy chain beta in uncontrolled HTN

A

Compliance (DECREASE)
ANGIO II/MYOSIN(INCREASE)
cuz decrease compliance

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2
Q

what do you expect to see in a graft when a reversible COMPETITIVE ANTAGONIST is + to FULL AGONIST

A

it will shift to the RT increase ED50 but NO change i the max effect(same height)

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3
Q

what type of collagen forms the scar after MI

A

I(tendon, ligaments, skin)

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4
Q

what are the chemokine receptor in HIV

A

CCR5, CXCR4

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5
Q

What lymphoma is ass w/ EBV/ and what abnormal cell will u see in the frontal lobe

A

Primary Central nervous system lymphoma(Lrg cell non-hodgkin lymphoma) increase in B cells cuz LYMPHOMA effects mostly B cells

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6
Q

Ventral Post. Thalamus can cause what type of stroke

A

PURE SENSORY!!!!

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7
Q

where does spinal stenosis occur most

A

lumbar region LIGAMENTUM FLAVUM HYPERTROPHY

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8
Q

SS of spinal stenosis

A

lower extremity pain, numbness/paresthesia, weakness(posture dependent standing, walking

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9
Q

MOA Amiloride Triamterene

A

K+ sparing (inhib epi Na+ channel preventing Na+ from entering=drives K+ secretion

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10
Q

Mushrooms(amatoxins) inhib what polymerase

A

RNA polymerase II( halts mRNA synthesis

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11
Q

DOC to slow down pulmonary fibrosis

A

PDGF, VEGF

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12
Q

what type of drug can you use break down empyema

A

TPA(fibrinolytic) decrease viscosity

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13
Q

how does PEEP help trt ARDS( what does it increase)

A

FRC

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14
Q

what can cause ARDS

A

sepsis, pneumo, trauma, PANCREATITIS

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15
Q

ARDS hv what type of lung mismatch

A

perfusion w/out VENTILATION

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16
Q

straw colored fluid is what type of pleura effusion

A

TRANSUDATE

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17
Q

if Leukocyte differential is mostly monocytes what type of effusion is it

A

TRANSUDATE

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18
Q

HIGH LDH is what type of effusion

A

ExUDATE

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19
Q

how do you differentiate sterile exudate in pleura space to bacterial invasion in pleural space

A

pH,>7.2 Glucose>60 WBCs<50,000 for STERILE. Bacteria is the opposite

20
Q

bleeding nipple what breast should u think of

A

intraductal papilloma(fingerlike fibrovascular projections)

21
Q

describe Phyllodes(benign) tumor of breast

A

overgrowth of fibrous component w/ leaf like projections

22
Q

Adipose tissue converts androgens to what in a women

A

ESTRONE(estrogen)

23
Q

what can you detect on DCIS

A

CALCIFICATION(necrosis/dystrophic ca+) NO BSMNT INVASION

24
Q

what;s the MC malignant breast cancer

A

IDCIS(forms duct like structures). nipple dimpling

25
what are the 4 subtypes of IDCIS
Tubular, Mucinous, Medullary Inflammatory
26
what are the 2 cell types seen in normal breast
epi/myoepi. (cancer only has 1)
27
what mutation does a pt w/medullary carcinoma of the breast hv
BRCA1/will also hv plasma/lymphocyte cells
28
what does LCIS lack
cadherin(low risk to carcinoma
29
ILCIS grows in what type of fashion /y?
Single file cuz it lacks cadherin cells don't stick 2gether
30
breast/ovarian has what type mutations
BRCA1
31
what mutations will u see in a male w/breast cancer
BRCA2
32
what hypersensitivity is Rheumatic fever
II
33
Pleomorphic adenoma is composed of what
MC tumor of parotid gland , chondromyxiod stroma(w/out Facial nerve palsy)
34
describe delta wave(WPW)
slurred upstroke of the QRS w/shortened PR interval
35
what's the nucleotide/mutation in frederick-ataxia
GAA/Frataxin gene(fe+)
36
what are the deformities of fredereick-ataxia(GAA)
Hammer toes, pes cavus, kyphoscoliosis
37
what should rt sided varicole raise suspicion for
renal carcinoma, lymphoma obstructing testicular vein
38
What's the haptoglobin lvl in mono(EBV)
decreases(hemolytic anemia)
39
what type of hypersensitivity is acute graft
IV (Th1 induced macrophage)
40
KIT mutation is ass w/ what
MASTOCYTOSIS
41
what is mastocytosis
proliferation of mast cells(rich in HISTAMINE) which can release gastric acid=gastric ulceration
42
what vit is a cofactor for cystathione synthase
B6
43
what enzyme is used to convert HOMOCYSTEINE to cysteine
Cystathionine Synthase(def causes Homocystiuria)
44
what causes def of hereditary FRUCTOSE intolerance
ALDOLASE B
45
Galactose-1 phospahte uridytrnsferase & Heredidaty Fructose intolerance present the same way what differentiate them
GUDPT is ealier(as soon breast feeding start cuz galactose) VS fructose is after when you start to introduce fruit to your baby
46
what ligament is usually involve in ovarian torsion
INFUNDIBULOPELVIC LIG