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wrong u//a Flashcards

1
Q

what happens to LV CO, SVR, LA filling in a PDA

A

CO, LA filling increases( cuz there’s more blood being dumped intoLA from pulmoary art) SVR DECREASES

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2
Q

what Ig does the Rh-mom get during prego w/Rh+ baby

A

IgG(although it crosses the placenta it does NOT cause significant hemolysis cuz the amt is not that much

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3
Q

GAS gangrene is specific to what bacteria

A

C. Perfringens

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4
Q

C.Perfringens causes gas gangrene how?

A

due to phosphilipase C. which splits host phopholipids and causes cell lysis & tissue necrosis

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5
Q

M3 causes you to pee through detrusor?

A

CONTRACTION

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6
Q

which receptor promotes activation of NO

A

M3(activate GMP—myosin light chain phosphotase(DEPHOSPHORYLATES myosin)-prvnts interaction of myosin w/actin =SM relaxation

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7
Q

which nerves/art are located in the cavernous sinus

A

III, IV, V1 V2 VI ICA

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8
Q

Aneurysm of the ICA in the cavernous sinus can effect which CN

A

VI causing weakness of LR6

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9
Q

what describes Ehrlichia Chaffeensis in blood microscopic

A

mulberry-shaped, intracytoplasmic inclusion in monocytes

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10
Q

B thalasemia effect what type of formation

A

mRNA(translation, transcription, processing)

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11
Q

Duchenne causes what types of mutations

A

NONSENSE/FRAMESHIT(MC)

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12
Q

What are the stop codons

A

UAA, UGA, UAG(NONSENSE MUTATIONS)

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13
Q

what is cryptorchidism

A

Testes that hv not descended to the scrotum. in ab

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14
Q

to fix Cryptochordism you must pass thru what

A

aponeurosis of EXTERNAL oblique

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15
Q

Propionyl-Coa is derived from what AA

A

Threonine, Isoleucine, Methionine, Valine & odd chain fatty acids

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16
Q

Propionyl-CoA carboylase is responsible for the conversion of what

A

Propionyl-CoA—–Methylmalonyl-CoA

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17
Q

what are the Typical High potency antipsychotics

A

Haloperidol, Trifluoperazine Fluphenazine (Hal Tries to Fly High)

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18
Q

what are SE of High potency antipsychotics

A

EPS(dystonia, akathasia, parkinsonism)

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19
Q

shaving, shirt collar, putting on a tie can cause the carotid baroreceptor to do what

A

increase PARASYMPA(syncope decrease SVR) cuz it thinks high BP

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20
Q

injury to the deep radial nerve can effect what muscle/what occupations

A

Supinator muscle (repetitive pronation/supination) frequent screwdriver use mechanics

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21
Q

what does elevated BP cause aortic barorecptors to do

A

causes stretching so aortic baro decreases sympa

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22
Q

what is decreased in serum sickness

A

C3 type III hypersensivity

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23
Q

manifestations of serum sickness

A

fever, pruitic rash, arthralgias 7-14 days after exposure to antigen

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24
Q

drugs that can cause serum sickness

A

Rituximab, infliximab(TNF-a) crohns. Venons, Serum like rxn drugs (pen, cefaclor, TMP-SMX)

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25
Q

what would histo show of serum sickness

A

fibrinoid necrosis/neutrophils

26
Q

where does Isotype switching occur

A

GERMINAL CENTERS!!!!!!!!

27
Q

what causes Bacillary Angiomatosis

A

Bartonella Henselae(cat scratch) similar to Kaposi sarcoma

28
Q

what labs are diagnositc for Hereditary spherocytocis

A

Decrease mean fluorescene of RBC in EMA, Increase fragility in Osmotic fragility test

29
Q

what is the purpose of Telomeres

A

they cause apoptosis thru shortened telomers after maximum LIMIT of proliferation. anything after that limit goes to apoptosis.

30
Q

what’s the level of telomeres in cancer cells

A

it’s high because Telomeres protect chrom from being recognized as damaged DNA

31
Q

prostate metastasise to bone will show what on histo

A

irregular glands w/enlarged nuclei & prominent nucleoli

32
Q

pericarditis due to malignancy(breast) will show what in a pericardiocentesis

A

Hemorrhagic fluid w/ atypical cells

33
Q

Purpura, Petechiae, Echymoses are a sign on what type of defect

A

PLATELETS

34
Q

what forms PLATELETS

A

MEGAKARYOCYTES

35
Q

what diz u’ll see MEGAKARYOCYTES

A

TTP, HUS, Bernard soulier

36
Q

MOA of Aspirin in plt aggregation

A

irreversibly blk COX(TX A2 is md from cox which calls in others to aggregate

37
Q

what is the end product of the coag cascade

A

THROMBIN

38
Q

Factor problems causes bleeding where?

A

muscles & joints rebeleding after surgery wisdom tooth extractions

39
Q

what kind of bleeding will you see in vWF(VIII) & what test will be abnormal

A

skin /mucosal bleeding abnormal ristocetin test INCREASE BT/PTT

40
Q

what’s the MC of inherited hypercoag state

A

mutated factor V leiden. does NOT hv cleavage site for protein C & S to cleave it

41
Q

what will you see in mom’s lungs that had PE due to delivery

A

squamous cells/keratin debris

42
Q

what are the nerves that DVT usually arise from

A

femoral, illiac popliteal

43
Q

why is PE clinically silent

A

cuz lung has dual blood supply pulmonary art/ bronchile art (coming from aorta)

44
Q

how does A-fib cause thrombosis

A

the heart is out of rythym so blood is stasis=coag

45
Q

if you lack sarcolemmal transverse tubules what will happen

A

impaired synchronization of cross-bridge formation

46
Q

what’s the MC of stress incontinence

A

Urethral hypermobility/ wknd pelvic floor

47
Q

what’s the ABG for an ACUTE opiod overdose

A

respiratory acidocis w/ NORMAL HCO3(it’s acute so compensation has not occured yet)

48
Q

PI(HIV) end in what

A

NAVIR(indinavir)

49
Q

what’s the problem in Keloid

A

increase production in hyalinized collagen(III &I)

50
Q

what’s the problem in hypertrophic scars

A

Ecess formation of organized extracellular matrix(III)

51
Q

where can u find Actinic Keratosis/increase risk of what cancer

A

Hand, scalp, face ears. squamous (if scrapes off it comes bk in few days) midly pruitic VS Lichen whose severly itchy

52
Q

what does Vaccination decrease

A

prevalence-positive predictive value

53
Q

proliferation of donor T lymphocyte is what type of rejection

A

Graft VS hOST(rash, dia, jaundice, hepato)

54
Q

what bone cancer is ass w/ pagets

A

OSTEOSARCOMA

55
Q

Does Pure Teratoma hv increase in testicular tumor markers

A

NO

56
Q

Burkitt lymphoma has what pattern

A

Starry sky

57
Q

Reed steinberg cells owel eye are found in what

A

HODGKIN LYMPHOMA CD 15, 30

58
Q

DOC for Stents /SE

A

Ticlopidine(ADP inhib) NEUTROPENIA/AGRANULOCYTOSIS, GI, rash, pruitis, anaphylais

59
Q

SE of Hydroyurea and what cycle does it work

A

Macrocytosis/S phase

60
Q

stress incontinence is caused by what muscle/nerve

A

Levator ani(pelvic floor muscle), external Urethral sphincter S2-S4 PUDENDAL

wrong (26 decks)

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