uworld/amboss Flashcards

(31 cards)

1
Q

what is Drug Reaction Eosinophilia Systemic Symptoms(DRESS SYNDROME)

A

drug rxn 2-8wks after drug exposure. (fever, lymphadenopathy, facial edema) rash

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2
Q

drugs that causes DRESS SYNDROME

A

phenytoin, carbamazepine, allopurinol, sulfasalazine, minocycline, vanco

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3
Q

Cutaneous neurofibroma are composed of what cells

A

Schwann cells

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4
Q

Methadone can cause what type of heart problem

A

Qt prolongation/torsade

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5
Q

what’s the cause of normal age related diminished antibody response to infections/vaccinations

A

Immunosenscense(Decrease PRODUCTION of naive B& T lymphocytes.

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6
Q

Mutation in TTN(titin) gene is ass w/ what heart problem

A

DIALATED CARDIO

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7
Q

SS of Dandy walker/ CT

A

non-communicating HYDROCEPHALUS. on CT lack of VERMIS(blk spot on the bk of the head)

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8
Q

what type of saline do you give for hypovolemia/shock

A

0.9%(normal saline) Lactated ringer solution

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9
Q

Symptoms/presentation/microscopy of AVM pts

A

seisures/headaches. Blood does not pass thru capillary bed. TANGLE of lrg blood vessels in THICKENED walls

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10
Q

Osteoprogrin does what to OSTEOCLAST/ RANK-L

A

inhibs osteoclast/ prevents RANK-L from binding to RANK

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11
Q

DOC/MOA for scabies

A

Permethrin(inhib Na+)

alternative drug Ivermectin(inhib CL-)

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12
Q

what nerve is effected when it’s compress due to obesity/tight clothing

A

Lateral Femoral Cutaneous nerve

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13
Q

what’s a value that’s normal in CO poisoning/anemia/polycythemia

A

partial pressure of O2 in he blood(PO2)

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14
Q

what supplies the papillary muscle

A

RCA-PDA(post. descending art)

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15
Q

thru what mechanisim is Vancomycin resistant

A

Transposition(plasmid encoded) alteration of peptidoglycan synthesis

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16
Q

what are the cancers that releases PTHrP

A

renal, bladder, ovarian, squamous cell of head neck, lung.

PTHrP does NOT simulate 25D to 1,25 so lvls will be low

17
Q

what’s the cause of Anencephaly & what kind of hydramniosis will you see

A

failure of rostral neuropore to close. Hole in the head(absence of forebrain) cannot swallow (POLYHYDRAMNIOSIS)

18
Q

Sudden painless loss of vision is called/cause

A

central retina art. occlusion/ thrombosis, vasculitis, fibromuscular dysplasia. Do a carotid art. ultrasonography

19
Q

what respiratory problem can an immature infant hv w/ mechanical ventilation use

A

BRONCHOPULMONARY DYSPLASIA

20
Q

what’s a SE(ion) of albuterol

21
Q

where is Hormone sensitive lipase found

A

adipose mobilized triglycerides in FFA /glycerol. FFA to acetyl-coA=Ketone bodies(gluconeogenesis)

22
Q

describe orphan Annie eye/what cancer

A

Lrg cell w/ nuclei containg finely dispersed chromatin/intranuclear inclusions. PAPILLARY CARCINOMA (MC)

23
Q

what contributes to the Hyperglycemia in glucocorticoids use

A

increase in epression of liver enzymes(gluconeogenesis)

24
Q

what enzyme converts Testosterone to DHT

25
how does pts w/5a reductase def present
Phenotypically/karyotipically male but FEMALE external(sml phallus,hypospadias)
26
SYMPTOMS OF VIPOMA
Watery Dia, Achylodria, Hypokalemia
27
what does Radioactive Iodine uptake measures(RAIU)
Organification of Iodine & synthesis of NEW (ENDOGENOUS) thyroid hormone
28
what's the level of RAIU inEXOGENOUS (hypothyroid drugs prescriptions)
Low because RAIU measures ENDOGENOUS thyroid
29
what's the level of RAIU in Gaves
INCREASE cuz ur mkng the Thyroid hormone
30
What's the levels for GnRH, LH, Testosterone in a prolactinoma
all decrease Tumors don't follow -fdbk
31
what is the Na+ level in Hyperaldosteronism(conn syndrome)
Normal due to aldosterone escape but HYPOKALEMIA/METABOLIC ALKALOSIS