Flashcards in Week 3 - Immune System Overview Deck (9)
What are the 3 basic layers of the immune system?
1. Physical Layer
2. Innate Immune System
3. Adaptive Immune System
What TLRs detect Bacterial Infections?
TLR4- LPS (gram negative)
TLR5 - Flagellins
What TLRs detect Viral Infections?
TLR9 - CpGRNA
TLR13 - dsRNA
(in an endosome)
What is the stratum corneum?
It is made up of dead cells/terminally differentiated/Non-living keratinocytes.
-Make up protective layer of skin
-Cells dry, regenerate, dec. pH, inc. salt
What does IL-2 do?
Proliferative - drives T cells to grow & divide
What does IL-12 do?
T cell differentiation to Th1
What does IL-4 do?
T cell differentiation to Th2
What are INF-gamma and TNF-beta?
Proinflammatory - Th1