Flashcards in Week 4 - MS Infectious Disease Deck (10):
What is the function of WBC? What is a normal WBC count? When do you have elevated WBC?
-Cells of the immune system defending the body against both infections and foreign materials
-Normal: 4,500-11,000 cells/ml
-Infections, inflammatory diseases, autoimmune systemic diseases, leukemia, and emotional & physical stress
What does a banded neutrophil look like in comparison to a mature neutrophil?
A banded neutrophil has one large lobe, not sectioned (shaped like a C). Meanwhile, a mature neutrophil is also lobular but it's sectioned into different chunks yet all lobes are still connected.
What is the composition of the WBC Count normally?
How is ESR calculated and what does it stand for?
Erythrocyte Sedimentation Rate
Rate at which RBC precip. in one hour when anti-coagulated blood is allowed to stand
What does ESR measure/indicate?
It measures abnormal acute phase proteins and immunoglobulins.
It's a nonspecific indicator of tissue damage & inflammation.
-Elevated in: anemia, endocarditis, kidney disease, osteomyelitis, pregnancy, etc.
What is normal ESR?
= 20 mm/hr
What is C-Reactive Protein (CRP)?
It is produced in the liver & present in circulation at low levels normally. It is involved in the promotion of the immune system through the activation of the complement cascade.
What is the normal amount of CRP?
= 1 mg/dL
When is CRP elevated?
Bacterial infections, inflammation conditions, acute rheumatic fever, acute rheumatoid arthritis, inflammatory bowel disease