Week 5 - AA Metabolites Flashcards Preview

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Flashcards in Week 5 - AA Metabolites Deck (11):
0

Which enzyme is most likely to release AA from membrane?

Phospholipase A2 (followed much later by Phospholipase C)

1

Which of the following is most likely to cause inflammation?

PGE2 - Prostaglandins

A tiny bit- Leukotrienes - related to asthma

2

What is most likely to cause an MI (myocardial infarction)?

Thromboxane A2 (causes clot) - promotes MI

Prostacyclin --> protects you against clots - prevents MI

3

COX 2 Inhibitors primarily block AA metabolism in endothelial cells to cause myocardial infarction. The synthesis of which of the following products is inhibited most:

Prostacyclin

4

What agents block cyclooxygenase and treat arthritis symptoms?

Ibuprofen, Naproxen, Celebrex

5

What pathway causes inflammation?

Arachidonic acid is produced which causes PGE2 to be produced which causes inflammation.

6

Which of the following suppresses both prostaglandin and leukotriene synthesis?

Prednisone - blocks both pathways

7

Which of the following selectively prevents leukotriene synthesis?

Zafirlukast & Zileuton

8

Which of the following relieves arthritis symptoms by reversibly blocking prostaglandin synthesis?

Ibuprofen

9

Which of the following both relieves arthritis symptoms and reduces risk of MI?

Acetylsalicylic acid (aspirin)

10

Which of the following is an effective arthritis treatment with the least risk of gastric ulceration?

Celecoxib (Celebrex)