Week 4 - Intro to Parasite Skin Infections Flashcards Preview

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Flashcards in Week 4 - Intro to Parasite Skin Infections Deck (8)
0

Why do antiparasitics often have side effects?

Parasites and eukaryotes and its difficult to find drugs with specificity against the parasite vs. the host

1

What is unique about parasites?

1.They can be difficult to classify because they cause disease in multiple systems
2. Can be unicellular or multicellular
3. Can be vector transmitted or acquired directly

2

If an antiparasite is given orally. . .

it must be well absorbed into the bloodstream. You have to consider whether it can kill all stages of the parasite & must be able to get where the organism is present

3

What groups do parasites most commonly occur in in the US?

Immigrants & people who have traveled to endemic areas

4

What is onchocerciasis treatment?

IVERmectin for rIVER blindness

5

What organism is associated with Chagas' disease and what is associated with African sleeping sickness?

Chagas - Trypanosoma cruzi
Sleeping Sickness - Trypanosoma brucei

6

What drug crosses the blood brain barrier and 5-10% of people who take it will get reactive encephalopathy and half of those will die? What does it treat?

Melarsoprol
-African Sleeping Sickness (African Trypanosomiasis)

7

What's the drug of choice for Chagas disease? What's its mechanism?

Nifurtimox
-causes oxidative stress by inhibiting NADPH dependent dehydrogenases and impairing the mitochondrial membrane potential - Benznidazole has similar mechanisms

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