Week 7- Approach to Coagulopathies Flashcards
(50 cards)
What are the three phases of the cell based model of coagulation
Initiation Amplification Propagation
What is primary haemostasis
Formation of a platelet plug at the site of vessel injury
What is secondary haemostasis
Cascade of clotting factors that stabilise the platelet plug with fibrin
What does fibrinolysis do
Breaks down fibrin to control clot size and remove clot
What are the components of primary haemostasis
Platelets Endothelium von Willebrand factor
What are the components of secondary haemostasis
Clotting factors produced by the liver
Which pathway does PT assess
Extrinsic and common pathway
Which pathway does aPTT assess
Intrinsic and common pathway
Which clotting factor has the shortest half life
Factor VII
What does a prolonged PT indicate
Defect in the extrinsic pathway
What does a prolonged aPTT indicate
Defect in the intrinsic pathway
What does prolonged PT and aPTT suggest
Common pathway or multiple factor deficiencies
Which factors are vitamin K dependent
Factors II VII IX X
What is the effect of rodenticide poisoning
Inhibits vitamin K recycling leading to coagulopathy
Which test is prolonged first in rodenticide poisoning
PT
Which dog breed is predisposed to von Willebrand disease
Doberman
What test is used to assess platelet and vessel function
Buccal mucosal bleeding time
What is the normal BMBT in dogs
2 to 4 minutes
What is the most likely cause of delayed bleeding 48 hours post op in a greyhound
Primary hyperfibrinolysis
What drug can treat hyperfibrinolysis
Tranexamic acid
What disease does SNAP 4Dx test for
Anaplasma Ehrlichia Lyme disease and heartworm
What blood smear finding may cause falsely low platelet count in cats
Platelet clumping
What is the significance of platelet count below 50000 per microlitre
Risk of spontaneous bleeding
What does petechiae indicate
Primary haemostatic disorder
