03c: Autonomic NS Flashcards Preview

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Flashcards in 03c: Autonomic NS Deck (29):
1

Somatic NS has (1/2/3) neuron(s) between CNS and target (X).

1;
X = skeletal muscle

2

Autonomic NS has (1/2/3) neuron(s) between CNS and target (X).

2;
X = smooth, cardiac muscles; and glands

3

T/F: Somatic NS only produces excitatory response (muscle contraction).

True

4

T/F: Autonomic nervous system only produces inhibitory response

False - excitatory or inhibitory

5

Most organs influenced by (Sympathetic/Parasympathetic) NS. List exceptions.

Both;
Adrenal medulla, sweat glands, blood vessels (only SNS)

6

Ratio of Pre/Post ganglionic fibers in sympathetic NS.

1:10

7

Ratio of Pre/Post ganglionic fibers in parasympathetic NS.

Nearly 1:1

8

Pre-ganglionic NT (going to post-ganglionic neuron) for sympathetic NS.

ACh

9

Pre-ganglionic NT (going to post-ganglionic neuron) for parasympathetic NS.

ACh

10

Post-ganglionic NT (going to effector organ) for parasympathetic NS.

ACh

11

Most common post-ganglionic NT (going to effector organ) in sympathetic NS.

NE

12

(Parasympathetic/Sympathetic) NS secretes (X) to target adrenal medulla. Adrenal medulla then secretes (Y) to (Z).

Sympathetic;
X = ACh
Y = Epi (80%): NE (20%)

Z = (Into) circulation

13

ACh has (X) types of receptors. List them and star the ones that are metabotropic.

X = 2

1. Nicotinic
2. Muscarinic*

14

Skeletal muscle has (X) type of ACh receptor, which is blocked by (Y).

X = N1 (nicotinic)
Y = curare

15

ANS ganglia have (X) type of ACh receptor, which is blocked by (Y).

X = N2 (nicotinic)
Y = hexamethonium

16

Smooth muscle has (X) type of ACh receptor, which is blocked by (Y).

X = muscarinic
Y = atropine

17

Cardiac muscle has (X) type of ACh receptor, which is blocked by (Y).

X = muscarinic
Y = atropine

18

NE has (X) types of receptors. List them and star the ones that are metabotropic.

X = 2

1. Alpha*
2. Beta*

19

When (X) activates Alpha-1 receptor, what happens?

X = NE

Leads to contraction of smooth muscle of blood vessels

20

Alpha-2 receptor found on (X) membrane. What happens when it's activated by (Y)?

X = adrenergic pre-synaptic membrane;
Y = NE

Acts as autoreceptor (inhibits NE release)

21

When (X) activates Beta-1 receptor, what happens?

X = NE

Increases HR and contraction F

22

When (X) activates Beta-2 receptor, what happens?

X = NE

Relaxes GI tract and some vascular smooth muscle

23

Binding of ACh to nicotinic receptors induces (EPSP/IPSP) in post-ganglionic cell.

EPSP

24

ACh binds (X) receptors in atria of heart and produces which response? The same receptors in intestinal smooth muscle produce which response?

X = muscarinic

Heart: decreases HR and contraction F
Intestine: increase frequency/F of contraction

25

Sympathetic post-ganglionic neurons release (X) NT from (Y), which look like pearls on a string and are located at axon's terminal.

X = NE
Y = varicosities (swellings)

26

List the factors that affect temporal release of NE from varicosities.

1. AP frequency
2. Amount of NE available
3. Other receptors on varicosity
4. Autoreceptors (NE concentration in cleft)
5. Factors that cause NE action termination

27

Termination of NE action affected by which mechanisms?

1. Reuptake by active transport
2. Diffusion from cleft
3. Extra-neuronal uptake and breakdown

28

NE reuptake into pre-synaptic cleft is broken down by:

Monoamine oxidase

29

T/F: Autonomic regulation of organs is typically initiatory.

false - modulatory