11 - Derm - Acne - Background Flashcards Preview

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Flashcards in 11 - Derm - Acne - Background Deck (7):
1

most common form? a disease of what? characterised by 3 things?

acne vulgaris
pilosebaceous glands
comedones, papules, pustules

2

effects % between 12-24? more common in who? more persistent in who?

85%
male
women - 10% may persist to 40's

3

4 myths of acne

only affects teens
caused by poor hygiene
caused by fatty foods
improved by drinking a lot of water

4

pathogenesis 3 steps?

1 - increase in sebum excretion rate SER
2 - ductal hypercornification
3 - proprionibacterium acnes infection

5

1 - increased SER - due to? results in?

increased circulating androgens or increased sensitivity to androgens
results in seborrhea (greasy skin)

6

2 - ductal hypercornification 4 steps

hyperkeratosis and abnormal desquamation of follicle
?free fatty acid levels in sebum association?
leads to obstruction of follicle and retention of sebum
results in comedone formation

7

3 - proprionibacterium acnes infection - 3 steps

- normally a commensal bacteria of skin
-thrives in obstructed follicle
-releases inflammatory mediators
-inflam - lead to follicular rupture and spread to surrounding dermis

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