28. Uric acid Flashcards
What is Uric Acid?
Final Product of Purine Base Metabolism
In Organism + FROM Food
Where are Purines Found?
Some Food and Drinks:
- Liver Meat
- Anchovies
- Mackerel
- Dried Beans + Peas
- Beer + Wine
What are the 2 Intermediate Products of Purine Base Metabolism?
- Xanthine = OXIDISED by Xanthine-Oxidase TO FORM Uric Acid
2. Hypoxanthine
Where Happens to the Uric Acid in the GI Tract?
DESTROYED by Uricase (Bacterial Enzyme)
FORMING Allantoin
What Happens if there is HYPERPRODUCTION of Uric Acid?
When Too Much is Produced
Kidney is unable to remove it from the Blood
Uric Acid Levels INCREASE in Blood
At What PLASMA Levels do Uric Acid Form Crystals?
ABOVE 430 µmol / L plasmas
Where it saturates, FORMING Urate Crystals
Precipitating in the Tissue
What are the Analytical Methods for Uric Acid Investigation?
Colorimetric
Enzymatic = Uricase
What Specimens are Required for Uric Acid Investigation?
Serum WITHOUT HEMOLYSUS
Urine
What are the Errors of Uric Acid Investigation?
TAGs
Keto-Acids
Lactate
- Which they COMPETE with Uric Acid IN Renal Tubules
What do the Competition of these Substances with Uric Acid, Result to?
Positive (+ve) FALSE Readings
How Do Uric Acid Levels Vary?
HIGH = In Morning
LOW = In Evening
What can INCREASE Uric Acid Levels?
Alcohol
Ascorbic Acid
Aspirin
What can DECREASE Uric Acid Levels?
Allopurinol
Azathioprine
Oestrogen
What is the Reference Range of Uric Acid in MALE?
208 - 387 μmol / L
What is the Reference Range of Uric Acid in FEMALE?
149 - 363 μmol / L
