Acute Tubular Necrosis Flashcards
1
Q
Most common cause of AKI seen in practie. TRUE/FALSE?
A
TRUE
2
Q
What does acute tubular necrosis mean?
A
Necrosis of renal tubular epithelial cells
3
Q
Two main causes of ATN
A
- ischaemia (shock/sepsis)
- nephrotoxins (aminoglycosides, rhabdomyolysis, contrast)
4
Q
Clinical features of AKI
A
Bloods show raised urea, creatinine, potassium
muddy brown casts in the urine
5
Q
Histopathological features
A
tubular epithelium necrosis: loss of nuclei and detachment of tubular cells from the basement membrane
dilatation of the tubules
necrotic cells obstruct the tubule lumen
6
Q
Name the 3 phases of ATN
A
oliguric phase
polyuric phase
recovery phase
7
Q
A
