p53 Flashcards
1
Q
is p53 an oncogene or tumour suppressor gene?
A
Tumour suppressor
2
Q
On which chromosome is p53 located
A
chromosome 17
3
Q
Cancers in which p53 is most commonly mutated
A
breast, colon and lung cancer
4
Q
when in the cell cycle is p53 thought to play a key role?
A
prevents entry into the S phase until DNA has been checked and repaired
Also a key regulator of apoptosis
5
Q
Autosomal dominant disorder caused by p53 mutation. Characterised by the early onset of a variety of cancers such as sarcoma, breast cancer and leukaemias
A
Li-Fraumeni syndrome
