Tumour suppressor genes Flashcards
1
Q
What are tumour suppressor genes? How do they cause cancer?
A
Genes which normally control the cell cycle
loss of their function = increased risk of cancer
NOTE: both alleles must be mutated before cancer occurs
2
Q
p53
A
Common to many cancers,
Li-Fraumeni syndrome (breast, sarcoma, leukaemia)
3
Q
APC
A
Colorectal cancer
4
Q
BRCA1/BRCA2
A
Breast and ovarian cancer
In men, there is an increased risk of breast cancer and prostate cancer
5
Q
NF1
A
Neurofibromatosis
6
Q
Rb
A
Retinoblastoma
7
Q
WT1
A
Wilm’s tumour
8
Q
Multiple tumor suppressor 1 (MTS-1, p16)
A
Melanoma
9
Q
A
