IL-1 Flashcards
1
Q
IL-1 is mainly secreted by which immune cell?
A
macrophages and monocytes
2
Q
Action of IL-1
A
- costimulator of T cell and B cell proliferation
- increases expression of adhesion molecules on the endothelium. - Stimulates release of vasoactive factors such as PAF, nitric oxide and prostacyclin
=> causes vasodilation and increases vascular permeability.
3
Q
IL-1 acts on the hypothalamus to cause pyrexia along with 2 other signally molecules. These other molecules are…
A
IL-6 and TNF
4
Q
Uses of IL-1 inhibitors
A
anakinra (IL-1 receptor antagonist)
- used in rheumatoid arthritis
canakinumab (monoclonal antibody targeted at IL-1 beta)
- used in systemic juvenile idiopathic arthritis and adult-onset Still’s disease
5
Q
A
