Cytokines Flashcards
From Macrophages
Function:
Acute inflammation
Induces fever
IL-1
from Th1 cells
Function:
Stimulates growth and differentiation of T cell response
IL-2
from Activated T helper cells
Function:
Stimulates differentiation and proliferation of myeloid progenitor cells
IL-3
From Th2 cells
Function:
Stimulates proliferation and differentiation of B cells
IL-4
From Th2 cells
Function:
Stimulate production of eosinophils
IL-5
From macrophages and Th2 cells
Function:
Stimulates differentiation of B cells
Induces fever
IL-6
From Macrophages
Function:
Neutrophil chemotaxis
IL-8
From Th2 cells
Function:
Inhibits Th1 cytokine production
Also known as human cytokine synthesis inhibitory factor and is an ‘anti-inflammatory’ cytokine
IL-10
From Dendritic cells, macrophages, B cells
Function:
Activates NK cells and stimulates differentiation of naive T cells into Th1 cells
IL-12
From Macrophages
Function:
Induces fever
Neutrophil chemotaxis
Tumour necrosis factor-α
From Th1 cells
Function:
Activates macrophages
Interferon-γ
