Antidiuretic hormone

Question 1

Synthesised in the______________

Answer 1

supraoptic nuclei of the hypothalamus

Question 2

Released by the ______________

Answer 2

Posterior pituitary

Question 3

Main function

Answer 3

Conserves body water

Question 4

Where does ADH promote water reabsorption?

Answer 4

collecting ducts of the kidneys

Question 5

How does ADH promote water reabsorption

Answer 5

insertion of aquaporin-2 channels

Question 6

Would the following circumstances increase or decrease the secretion of ADH?

extracellular fluid osmolality increase
volume decrease
pressure decrease
angiotensin II

Answer 6

increase (=> more water retention)

Question 7

Would the following circumstances increase or decrease the secretion of ADH?

extracellular fluid osmolality decrease
volume increase
temperature decrease

Answer 7

Decrease (=> more fluid loss)

Question 8

Describe the difference between cranial Diabetes Insipidus and Nephrogenic Diabetes insipidus

Answer 8

CRANIAL = deficiency of antidiuretic hormone (ADH)
Nephrogenic = inability of kidneys to respond to ADH

Question 9

Treatment for cranial diabetes insipidus (i.e. ADH deficiency)?

Answer 9

Desmopressin (analog of ADH)