Leukotrienes Flashcards
1
Q
Functions of leukotrienes
A
- mediators of inflammation and allergic reactions
- cause bronchoconstriction, mucous production
- increase vascular permeability, attract leukocytes
2
Q
What cells secrete leukotrienes?
A
leukocytes
3
Q
What pathway is responsible for the formation of leukotrienes
A
arachidonic acid metabolism by lipoxygenase
4
Q
Why is NSAID induced bronchospasm in asthmatics thought to be due to leukotrienes
A
secondary to the express production of leukotrienes due to the inhibition of prostaglandin synthetase
