232b cytopathology of cancer Flashcards Preview

heme/onc > 232b cytopathology of cancer > Flashcards

Flashcards in 232b cytopathology of cancer Deck (11):
1

tumor vs neoplasm

tumor - palpable mass of any type

neoplasm - palpable mass of monoclonal proliferation

2

benign vs malignant

malignant - invades and destroys local tissue, can metasize, necrosis of tumor

3

carcinoma - cell type and spread?

epithelial cells

lymph

4

sarcoma - cell type and spread?

mesenchymal

blood

5

what are benign vs malignant nevus growths?

benign - melanocytic nevus

malignant - melanoma

6

how are malignant tumor behaviors predicted?

differentiation: well=resembles tissue of origin

grade: pleomorphism, cellularity, differentiation, mitotic activity, etc.

stage: TNM system

7

monoclonal antibodies as drugs - ending? target?

"_ab"

against proteins on cell surface (large size impedes crossing cell membrane)

8

small molecule inhibitors as drugs - ending? target?

"_ib"

blocks ATP-binding sites --I disrupts tyrosine kinase signaling pathways

9

trastuzumab - target? cancers?

HER2 amplification cancer

breast adenocarcinoma
esophageal/gastric adenocarcinoma

10

Gefitinib/vemurafenib - target? cancer?

EGFR/B-RAF mutations

lung adenocarcinoma

11

Imatinib - target? cancer?

c-KIT overexpression

CML/GI stromal tumor