Flashcards in 232b cytopathology of cancer Deck (11):
tumor vs neoplasm
tumor - palpable mass of any type
neoplasm - palpable mass of monoclonal proliferation
benign vs malignant
malignant - invades and destroys local tissue, can metasize, necrosis of tumor
carcinoma - cell type and spread?
sarcoma - cell type and spread?
what are benign vs malignant nevus growths?
benign - melanocytic nevus
malignant - melanoma
how are malignant tumor behaviors predicted?
differentiation: well=resembles tissue of origin
grade: pleomorphism, cellularity, differentiation, mitotic activity, etc.
stage: TNM system
monoclonal antibodies as drugs - ending? target?
against proteins on cell surface (large size impedes crossing cell membrane)
small molecule inhibitors as drugs - ending? target?
blocks ATP-binding sites --I disrupts tyrosine kinase signaling pathways
trastuzumab - target? cancers?
HER2 amplification cancer
Gefitinib/vemurafenib - target? cancer?