Flashcards in 274b hodgkin lymphoma Deck (11):
CD20 = b cell
CD3 = t cell (cytoplasm in immature, surface in mature T cells) plus CD2,3,5,7
TDT = marker of lymphoblastic leukaemia/lymphoma (young cells); negative = peripheral/more mature T cell lymphoma
adult t-cell lymphoma - who gets it?
adults - long latency
adult t-cell lymphoma - what causes it?
HTLV1 (w/ IV drug use or breast milk) --> CD4+ T cells lose CD7 marker
adult t-cell lymphoma - presentation? where? nuclei appearance?
cutaneous lesions, lytic bone lesions, hypercalcemia
Japan, West Africa, Caribbean
flower shaped nuclei in T cells
Mycosis fungoides/Sezary syndrome - what is it?
neoplasm of mature T-cells --> CD4+
Mycosis fungoides/Sezary syndrome - who gets it?
Mycosis fungoides/Sezary syndrome - presentation? disease outcome?
cutaneous patches, plaques, tumors --> spread to lymph nodes and viscera
Hodgkin Lymphoma - cell origin?
Hodgkin Lymphoma - cell?
2 halves as mirror images --> owl eye
Hodgkin Lymphoma - classification?
nodular lymphocyte predominant --> good prognosis; 5%; popcorn cells, not reed-sternberg
classical - 95%; bimodal distro; mediastinal mass; nodular sclerosing form is most common