274b hodgkin lymphoma Flashcards Preview

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Flashcards in 274b hodgkin lymphoma Deck (11):
1

cell markers
CD 20
CD3
TDT

CD20 = b cell

CD3 = t cell (cytoplasm in immature, surface in mature T cells) plus CD2,3,5,7

TDT = marker of lymphoblastic leukaemia/lymphoma (young cells); negative = peripheral/more mature T cell lymphoma

2

adult t-cell lymphoma - who gets it?

adults - long latency

3

adult t-cell lymphoma - what causes it?

HTLV1 (w/ IV drug use or breast milk) --> CD4+ T cells lose CD7 marker

4

adult t-cell lymphoma - presentation? where? nuclei appearance?

cutaneous lesions, lytic bone lesions, hypercalcemia

Japan, West Africa, Caribbean

flower shaped nuclei in T cells

5

Mycosis fungoides/Sezary syndrome - what is it?

neoplasm of mature T-cells --> CD4+

6

Mycosis fungoides/Sezary syndrome - who gets it?

adults

7

Mycosis fungoides/Sezary syndrome - presentation? disease outcome?

cutaneous patches, plaques, tumors --> spread to lymph nodes and viscera

indolent

8

Hodgkin Lymphoma - cell origin?

B cell

9

Hodgkin Lymphoma - cell?

reed-sternberg cell

2 halves as mirror images --> owl eye

CD15+, CD30+

10

Hodgkin Lymphoma - classification?

nodular lymphocyte predominant --> good prognosis; 5%; popcorn cells, not reed-sternberg

classical - 95%; bimodal distro; mediastinal mass; nodular sclerosing form is most common

11

Hodgkin Lymphoma - which has best prognosis?

nodular lymphocyte