283b thrombophilia Flashcards Preview

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Flashcards in 283b thrombophilia Deck (11):
1

thrombodulin

activates TAFI --I plasmin
activates Protein C --I thrombus formation

2

arteria thrombis

artery - platelet driven; wall atherosclerosis --> MI, stroke, gangrene

risks - htn, lipids, DM, hyperhomocysteinemia

3

adiponectin

blocks platelet aggregation and increased insulin sensitivity

fat people has low adiponectin --> thromus and inflammation --> atherothbombosis

4

venous thromosis

fat, OCP, older age, cancer, trauma, surgery

5

genetic factors for VTE

gain of function - factor V leiden, prothrombin 20210A

loss of fxn - Ptn C, S, antithrombin

6

Factor V Leiden - cause? who gets it?

mutant factor V --> resistant to degradation by activated protein C.

Most common cause of inherited hypercoagulability in whites.

7

FV leiden and OCPs

dramatically increases risk, but still low prevalence

8

Prothrombin G20210A gene mutation? who gets it?

Mutation in 3′ untranslated region --> increases production of prothrombin --> increase plasma levels and venous clots

hispanics

9

Antithrombin deficiency

Inherited deficiency of antithrombin: has no direct effect on the PT, PTT, or thrombin time but diminishes the increase in PTT following heparin administration.

Can also be acquired: renal failure/nephrotic syndrome --> antithrombin loss in urine --> increased factors II and X.

10

Protein C or S deficiency

can't inactivate factors V and VIII.

increased risk of thrombotic skin necrosis with hemorrhage following administration of warfarin.

Skin and subcutaneous tissue necrosis after warfarin administration--> think protein C deficiency. “Protein C Cancels Coagulation.”

11

homocysteine-metabolism

homocysteine - methionine OR cystathionine

1- MTHF reductase
B12, folate

2- cystathionine synthase
B6

increased risk of thrombosis b/c damages endothelium