256b sarcoma Flashcards Preview

heme/onc > 256b sarcoma > Flashcards

Flashcards in 256b sarcoma Deck (13):
1

sarcoma - who gets more?

old people but young people with cancer have a higher percentage of sarcoma

2

what is mutated in Li-Fraumeni syndrome?

p53 mutation - tumor suppressor gene (need 2 bad copies for cancer development)

3

vinyl chloride - cancer risk?

hepatic angiosarcoma

4

what is the most common soft tissue mass?

lipoma (< 5 cm, constant size, not painful)

5

Gastrointestinal stromal tumor - gene mutation? gene product?

c-kit

cytokine receptor for stem cell factor

6

what is the only to cure soft tissue sarcoma?

surgery - must have negative margins or else send back for more surgery

7

Imatinib (gleevec) - mechanism? clinical use? toxicity?

tyrosine kinase inhibitor (occupies ATP binding site) of bcr-abl (CML) and c-kit (GIST)

CML, GIST

fluid retention

8

Gastrointestinal stromal tumor - gene mutation? gene product?

c-kit

cytokine receptor for stem cell factor

9

osteosarcoma - location? who gets it? characteristics? rx?

aggressive malignant bone tumor at metaphysis of long bone around the knee

bimodal (65 years old)

codman triangle -- elevates periosteum/sunburst pattern on x-ray

rx - surgical en bloc resection + chemotherapy

10

chondrosarcoma - location? who gets it? characteristics?

rare, malignant cartilage tumor in diaphysis

men 30-60 years old

can be from osteochondroma (rarely)
expansile glistening mass within the medullary cavity of bone

11

what tumors occur at the epiphysis/metaphysis?

epi - Giant cell tumor (soap bubble) - benign

meta - osteosarcoma (malg) and osteochondroma (exostosis, benign)

12

what two malignant tumors occur in the diaphysis of long bones?

ewing sarcoma

chondrosarcoma

**both malignant**

13

Giant cell tumor of bone - location? who gets it? characteristics?

benign bone tumor at epiphyseal of long bones

20-40 years old

locally aggressive around the knee
soap bubble appearance on x-ray
multinucleated giant cells