256b sarcoma Flashcards
sarcoma - who gets more?
old people but young people with cancer have a higher percentage of sarcoma
what is mutated in Li-Fraumeni syndrome?
p53 mutation - tumor suppressor gene (need 2 bad copies for cancer development)
vinyl chloride - cancer risk?
hepatic angiosarcoma
what is the most common soft tissue mass?
lipoma (< 5 cm, constant size, not painful)
Gastrointestinal stromal tumor - gene mutation? gene product?
c-kit
cytokine receptor for stem cell factor
what is the only to cure soft tissue sarcoma?
surgery - must have negative margins or else send back for more surgery
Imatinib (gleevec) - mechanism? clinical use? toxicity?
tyrosine kinase inhibitor (occupies ATP binding site) of bcr-abl (CML) and c-kit (GIST)
CML, GIST
fluid retention
Gastrointestinal stromal tumor - gene mutation? gene product?
c-kit
cytokine receptor for stem cell factor
osteosarcoma - location? who gets it? characteristics? rx?
aggressive malignant bone tumor at metaphysis of long bone around the knee
bimodal (65 years old)
codman triangle – elevates periosteum/sunburst pattern on x-ray
rx - surgical en bloc resection + chemotherapy
chondrosarcoma - location? who gets it? characteristics?
rare, malignant cartilage tumor in diaphysis
men 30-60 years old
can be from osteochondroma (rarely)
expansile glistening mass within the medullary cavity of bone
what tumors occur at the epiphysis/metaphysis?
epi - Giant cell tumor (soap bubble) - benign
meta - osteosarcoma (malg) and osteochondroma (exostosis, benign)
what two malignant tumors occur in the diaphysis of long bones?
ewing sarcoma
chondrosarcoma
both malignant
Giant cell tumor of bone - location? who gets it? characteristics?
benign bone tumor at epiphyseal of long bones
20-40 years old
locally aggressive around the knee
soap bubble appearance on x-ray
multinucleated giant cells
