282b - thrombotic disorders Flashcards Preview

heme/onc > 282b - thrombotic disorders > Flashcards

Flashcards in 282b - thrombotic disorders Deck (14):
1

ADAMSTS13 fxn? location?

cleaves vWF to make it less efficient in causing clots

surface of endothelium cell

2

thrombomodulin fxn

binds thrombin and inhibits it

3

physiologic anticoagulants - ATIII fxn? drug that acts on it?

ATIII - serine protease inhibitor (II, X, IX, XI, CII, VII-TF); heparin makes it much more active

4

physiologic anticoagulants - protein C fxn? what activates it? cofactor?

activates Protein C,S --I V, VIII

thrombomodulin - formed with thrombin --> activates Protein C

prtn S - circulating free (1/3) --> cofactor for protein C

5

fibrinolytic system - what breaks up clots? what increases? decreases?

breaks up fibrin via plasmin --> releases D-dimer

tPA, urokinase increases plasmin

Plasminogen activator inhibitor blocks plasmin

6

where do thrombi form? what is present in this area to prevent thrombi formation?

vein valve sinus - low vWF and high TM and EPCR to try to stop this

7

preg and thrombus location?

left iliac artery crosses over and on top of left iliac vein --> occludes vein

8

what kind of surgeries give DVTs?

orthopedic surgeries of hip and LE

9

veins in leg?

superficial veins - greater and lesser saphenous veins

deep veins - iliac, superficial femoral, popliteal, tibial (deep femoral vein is very short and uncommon location for DVT)

10

DVT locations?

popliteal, superficial femoral, iliac are common places

11

DVT symptoms? PE?

unilateral leg swelling, warmth, pain, discoloration

PE - cough, SOB,pleuritic chest pain

12

lab test for DVT

d-dimer

legs --> US - press down which should compress vein but not artery unless DVT

lung --> CT pulmonary angiograms via dye in arm

13

VTE complications

PE

Pulmonary HTN - recurrent PE -> destroys lungs

recurrence - high without treatment

14

Post-thombus syndrome

doesn't go away - occludes blood flow --> ulcers, swelling, itching