Flashcards in 244b tumor immunology Deck (10):
cells of innate vs adaptive immunity
innate = dendritic cells, macrophages, NK cells
adaptive = T and B cells
immune surveillance and cancer
weak immune --> higher risk of cancer (HIV, organ transplants)
prognosis and immune cell counts
high CD8 cell count is good
high Th (1/2/17) cells is bad
induction phase (lymph nodes)- APC presents tumor on MHC with costimulator to CD8 + CD4 cells secrete cytokines to stimulate CD8
effector phase - CD8 differentiated and recognize tumor cells
tumor intrinsic escape mechanisms
loss of tumor antigens, loss of MHC I, more Bcl-2, etc...
tumor-induced immune subversion
tumor secretes cytokines that regulate immune system (IL-10, TGF-B), release ROS, etc...
active - vaccination with Ag from killed tumor cells - can use dendritic cells with antigen, viral vectors, DNA vaccines, etc
passive - give antibodies, adoptive t cell therapy
monoclonal antibody against tumor - what can be attached to the antibody?
can give just ab (--> phagocytosi, complement activation, ADCC)
can couple to toxin that will kill tumor cell
can conjugate to radioisotope that releases radiation to kill tumor
anti-PD-1 and anti-CTLA-4 antibodies for cancer treatment
block signal on CTLA-4 (B-7) and PD-1 --> increased immune response
PD-1 and B7/CTLA-4 normally suppress T cell response