257b paraneoplastic Flashcards Preview

heme/onc > 257b paraneoplastic > Flashcards

Flashcards in 257b paraneoplastic Deck (15):
1

Paraneoplastic syndrome -1,25 OH D3 (calcitriol)
effect? neoplasm?

hypercalcemia

hodgkin lymphoma, non-hodgkin lymphoma

2

Paraneoplastic syndrome -ACTH
effect? neoplasm?

Cushing's syndrome

small cell lung carcinoma

3

Paraneoplastic syndrome -ADH
effect? neoplasm?

SIADH

small cell lung carcinoma
intracranial neoplasm

4

Paraneoplastic syndrome -Abs --> Ca channels at NMJ -
effect? neoplasm?

LEMS (muscle weakness)

small cell lung carcinoma

5

Paraneoplastic syndrome -EPO
effect? neoplasm?

polycythemia

RCC
thymoma
hemangioblastoma
HCC
leiomyoma
pheochromocytoma

6

Paraneoplastic syndrome -PTHrP
effect? neoplasm?

hypercalcemia

squamous cell lung carcinoma
RCC
Breast cancer

7

what cancer is associated with myasthenia gravis?

thymoma

8

paraneoplastic cerebellar degeneration - symptoms? what is targeted in brain?

dysarthria
truncal, limb, gait ataxia
vertigo
diplopia

Anti-purkinje cell abs

9

paraneoplastic - limbic encephalitis
symptoms?

psychiatric
MS changes/memory loss
seizures

various abs against GABA receptor, NMDA, etc.

10

LEMS - symptoms? cause?

muscle weakness below the neck that improves with exercise
dry mouth

Ab --> reduced Ca channels on presynaptic terminal

11

sensory neuronopathy - symptoms? pathophysiology?

painful paresthesias and sensory loss

anti-hu (small cell lung cancer)

12

acanthosis nigricans - appearance? cancers that can cause it?

brown velvety hyperpigmented skin at armpits, groin, navel, neck

GI malignancies
OR hyperinsulonmeia (DM, obesity, cushings)

13

dermatomyositis - what does it effect? labs? cancer causes? abs?

inflammation of muscles and skin

increased CPK, ESR

adenocarcinoma of breast, lung, ovarian

Anti-Jo-1, anti-SRP, anti-Mi-2

14

Cushing Syndrome - symptoms? lab? cancer cause?

muscle weakness, edema, HTN, fat face, back hump

hypokalemia (increased insulin drives K into cells)

ectopic ACTH (SCLC, neuro-endocrine)

15

SIADH - symptoms, lab, tumors?

unsteady gait, HA, nausea, confusion, seizures

low Na, increased urine concentration --> increased volume decreases aldosterone --> low Na --> cerebral swelling (correct slowly to prevent central pontine myelinolysis)

tumors: SCLC --> ADH + ANP
head trauma
pulmonary diseases
drugs (cyclophosphamide

Rx - restrict fluids, IV saline, conivaptan, tolvaptan, demeclocycline