Flashcards in 235b viral oncogenes Deck (19):
1
EBV
virus type? genetic material?
disease?
associated cancer?
Herpesvirus, DNA
causes mononucleosis
Burkitt lymphoma (8:14, MYC and Ig translocation in B-cells, starry sky pattern in histo, think HIV)
hodgkin lymphoma
nasopharyngeal carcinoma
CNS lymphoma + oral hairy leukoplakia in immunocompromised
2
HBV, HCV
virus types? genetic material? spread?
associated cancer?
vaccine?
carrier?
HBV= hepadnavirus; DNA --> integrates into host genome + chronic inflammation --> cancer; sexual
HCV=flavivirus, RNA, doesn't integrate but causes chronic inflammation --> cancer; blood
HCC
vaccine for HBV
HBV = Babies become carrier
HCV= yes, integrates into genome
3
HHV-8 (kaposi sarcoma - associated herpesvirus)
virus type? genetic material?
associated cancer?
herpesvirus, DNA
kaposi sarcoma
body cavity B-cell lymphoma
4
HPV
virus type? genetic material?
virus products?
disease?
associated cancer?
papillomavirus, DNA virus
E6--I p53
E7--I Rb
causes condylomata acuminata (6, 11)
cervical and penile/anal carcinoma (16, 18)
head and neck/throat cancer
5
H Pylori
associated cancer?
gastric adenocarcinoma and MALT lymphoma
6
HTLV-1
virus type? genetic material?
associated cancer?
Retrovirus, RNA virus
adult t-cell leukemia/lymphoma
7
liver fluke (clonorchis sinensis)
associated cancer?
cholangiocarcinoma
8
schistosoma haematobium
associated cancer?
bladder cancer (squamous cell)
9
what percentage of cancers are associated with viruses? virus sufficient for cancer?
15%
necessary but not sufficient (correlative relationship, not causative)
not all tumors (Brukett's) have a viral component
10
human herpesviruses - what group causes cancer? what viruses specifically?
Gamma
EBV
HHV-8/KSHV
10
human herpesviruses - what group causes cancer? what viruses specifically?
Gamma
EBV
HHV-8/KSHV
11
EBV - what does it infect? how does it cause cancer?
oral epithelium --> b cells; virus mimics BCR and CD40 signals via LMP which activates b cells and leads to cell differentiation and growth
11
EBV - what does it infect? how does it cause cancer?
oral epithelium --> b cells; virus mimics BCR and CD40 signals via LMP which activates b cells and leads to cell differentiation and growth
12
HBV, HCV treatments
Interferon-a : HBV, HCV -- blocks protein synthesis
ribavirin: HCV, blocks nucleic acid synthesis via guanine nucleotide synthesis
12
Burkitt lymphoma - virus association? mutation? presentation?
EBV
8:14, MYC and Ig translocation in B-cells, starry sky pattern in histo, think HIV
jaw lesion in dendmic form in africa
pelvis or abdomen in sporadic
13
Kaposi sarcoma - virus? presentation?
HHV-8
endothelial neoplasm in HIV/transplants
dark flat lesions on skin
14
HBV, HCV treatments
Interferon-a : HBV, HCV -- blocks protein synthesis
ribavirin: HCV, blocks nucleic acid synthesis via guanine nucleotide synthesis
15
ribavirin - mechanism? clinical use? toxciity?
mechanism: --I synthesis of guanine nucleotides by --I inosine monophosphate dehydrogenase
use: RSV, HCV chronic infection
toxicity: hemolytic anemia, severe teratogen
19