235b viral oncogenes Flashcards Preview

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Flashcards in 235b viral oncogenes Deck (19):
1

EBV
virus type? genetic material?
disease?
associated cancer?

Herpesvirus, DNA

causes mononucleosis

Burkitt lymphoma (8:14, MYC and Ig translocation in B-cells, starry sky pattern in histo, think HIV)
hodgkin lymphoma
nasopharyngeal carcinoma
CNS lymphoma + oral hairy leukoplakia in immunocompromised

2

HBV, HCV
virus types? genetic material? spread?
associated cancer?
vaccine?
carrier?

HBV= hepadnavirus; DNA --> integrates into host genome + chronic inflammation --> cancer; sexual

HCV=flavivirus, RNA, doesn't integrate but causes chronic inflammation --> cancer; blood

HCC

vaccine for HBV

HBV = Babies become carrier
HCV= yes, integrates into genome

3

HHV-8 (kaposi sarcoma - associated herpesvirus)
virus type? genetic material?
associated cancer?

herpesvirus, DNA

kaposi sarcoma
body cavity B-cell lymphoma

4

HPV
virus type? genetic material?
virus products?
disease?
associated cancer?

papillomavirus, DNA virus

E6--I p53
E7--I Rb

causes condylomata acuminata (6, 11)

cervical and penile/anal carcinoma (16, 18)
head and neck/throat cancer

5

H Pylori
associated cancer?

gastric adenocarcinoma and MALT lymphoma

6

HTLV-1
virus type? genetic material?
associated cancer?

Retrovirus, RNA virus

adult t-cell leukemia/lymphoma

7

liver fluke (clonorchis sinensis)
associated cancer?

cholangiocarcinoma

8

schistosoma haematobium
associated cancer?

bladder cancer (squamous cell)

9

what percentage of cancers are associated with viruses? virus sufficient for cancer?

15%

necessary but not sufficient (correlative relationship, not causative)

not all tumors (Brukett's) have a viral component

10

human herpesviruses - what group causes cancer? what viruses specifically?

Gamma

EBV
HHV-8/KSHV

10

human herpesviruses - what group causes cancer? what viruses specifically?

Gamma

EBV
HHV-8/KSHV

11

EBV - what does it infect? how does it cause cancer?

oral epithelium --> b cells; virus mimics BCR and CD40 signals via LMP which activates b cells and leads to cell differentiation and growth

11

EBV - what does it infect? how does it cause cancer?

oral epithelium --> b cells; virus mimics BCR and CD40 signals via LMP which activates b cells and leads to cell differentiation and growth

12

HBV, HCV treatments


Interferon-a : HBV, HCV -- blocks protein synthesis

ribavirin: HCV, blocks nucleic acid synthesis via guanine nucleotide synthesis

12

Burkitt lymphoma - virus association? mutation? presentation?

EBV

8:14, MYC and Ig translocation in B-cells, starry sky pattern in histo, think HIV

jaw lesion in dendmic form in africa
pelvis or abdomen in sporadic

13

Kaposi sarcoma - virus? presentation?

HHV-8

endothelial neoplasm in HIV/transplants

dark flat lesions on skin

14

HBV, HCV treatments


Interferon-a : HBV, HCV -- blocks protein synthesis

ribavirin: HCV, blocks nucleic acid synthesis via guanine nucleotide synthesis

15

ribavirin - mechanism? clinical use? toxciity?

mechanism: --I synthesis of guanine nucleotides by --I inosine monophosphate dehydrogenase

use: RSV, HCV chronic infection

toxicity: hemolytic anemia, severe teratogen

19

JC virus
virus type? genetic material?
disease?

polyomavirus, DNA

progressive multifocal leukoencephalopathy (PML) in HIV --> death; virus is reactivated when get immunocompromised

"JC=Junky Cerebrum"
"Don't you Need A little JC" (DNA virus)