275b CLL Flashcards Preview

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Flashcards in 275b CLL Deck (19):
1

Chronic Lymphoid Leukemia - mature or blast cells? what kind of cells? where is the disease? who gets it?

mature - B cells

blood + BM

older adults

2

Chronic Lymphocytic Leukemia (CLL) - Age?

> 60 years

3

Chronic Lymphocytic Leukemia (CLL) - what kinds of cells? how is small lymphocytic lymphoma different (SLL)?

B-cells: CD 19, 20+, CD5+ (normally on T-cells)

SLL is in lymph node not BM

4

Chronic Lymphocytic Leukemia (CLL) - peripheral blood smear?

CLL cells look normal, but are more fragile --> smudge cells

5

Chronic Lymphocytic Leukemia (CLL) - presentation?

often asymptomatic-- progresses slowly

infections late in disease - bacterial usually

6

Hairy Cell Leukemia - cell appearance? stain?

filamentous, hair like projections

TRAP +

7

Hairy Cell Leukemia - RX?

cladribine (2-CDA)

purine (adenosine) analog --I adenosine deaminase

8

Chronic Lymphocytic Leukemia (CLL) - peripheral blood smear?

CLL cells look normal, but are more fragile --> smudge cells

9

Adult T-cell leukemia/lymphoma - what kind of cells? who gets it? what causes it?

mature T cells

adults

HTLV-1 (w/ IV drug use) --> intergrates into T cell DNA

10

Chronic Lymphocytic Leukemia (CLL) - presentation?

often asymptomatic-- progresses slowly

infections late in disease - bacterial usually

11

Adult T-cell leukemia/lymphoma - presentation? smear appearance?

cutaneous lesions

lytic bone lesions --> hypercalcemia

"flower" appearance of lymphocytes

12

Sezary Syndrome/Mycosis fungoides - cells?

mature T cells, CD4+

cutaneous lymphoma (itching) --> spreads to nodes and viscera (organomegaly)

indolent

13

?Hairy Cell Leukemia - RX?

cladribine (2-CDA)

purine (adenosine) analog --I adenosine deaminase

14

Large Granular Lymphocyte Leukemia - cells? clinical presentation? smear?

T cell

neutropenia --> recurrent infections

larger lymphocyte with granules

15

Adult T-cell leukemia/lymphoma - what kind of cells? who gets it? what causes it?

mature T cells

adults

HTLV-1 (w/ IV drug use)

16

Adult T-cell leukemia/lymphoma - geographic location?

Japan, West Africa, the Carribean

17

Adult T-cell leukemia/lymphoma - presentation?

cutaneous lesions

lytic bone lesions --> hypercalcemia

18

Sezary Syndrome/Mycosis fungoides - cells?

mature T cells, CD4+

cutaneous lymphoma (itching) --> spreads to nodes and viscera (organomegaly)

indolent

19

Sezary Syndrome/Mycosis fungoides - cell appearance?

large cell with many convolutions --> brain like