4/10 Flashcards
(29 cards)
competency
determined by a court, not a doctor
drug induced lupus vs non drug induced lupus antibodies
drug = H1 histone linker antibodies non = Smith
MOA of ribavarin
same as mycophenolate, conversion of IMP to GMP
urine dicarboxylic acids
present in MCAD deficiency due to omega decarboxylation because can’t break down fatty acids
presentation of methylmalonyl CoA mutase deficiency
- early in life
- severe acidosis
- hyperammonia
- high MMA in urine
garlic odor on breath
arsenic poisoning
mechanism of arsenic poisoning
- binds lipoic acid
TCA enzymes requiring CO2
isocitrate dehydrogenase and alphaketoglutarate dehydrogenase
uncoupling agents
dinitrophenol and aspirin and brown fat
Pompe’s trashes the….
pump (cardiomegaly)
how fats and amino acids get into TCA cycle
succinyl CoA (can’t use acetyl CoA)
sodium dependent glucose pumps are in…
instestines
mcardles vs carnitine deficiency
mcardle’s = glycogen, carnitine = lipids
egg whites prevent…
biotin absorption
sources for gluconeogenesis
- alanine
- lactate
- odd chain fatty acids
- glycerol
mechanism of gout in alcoholics
increase in NADH/NAD ratio leads to increase in lactic acid which competes with gout for trasnport leading to less excretion
first step after glycolysis that occurs in mitochondria
pyruvate dehydrogenase
isolated hyperammonemia
urea cycle disorder
substitution in sickle cell
valine for glutamic acid
vitamin that requires a kinase
B6
B vitamin that can cause toxicity
B6 - peripheral neuropathy
product of HMG CoA reductase
mevalonic acid
rule of the pupil
in compression due to aneurysms, parasympathetic fibers are compressed and pupil is affected
- in diabetes, motor portion is most affected, pupil is spared
pulsus paradoxus in lung disease
asthma and COPD
