Lecture 2/3-properties Of Biological Molecules I&II Flashcards

1
Q

Standard free-E* change equation

A

Delta G = -(R)(T)ln(Keq)

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2
Q

Gibbs Free E* equation

A

Delta G=Delta G*‘+ln([Prod]/[React])

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3
Q

Three types of non-covalent bonds

A

Hydrophobic interactions, van der Waal’s, electrostatic interactions

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4
Q

What produces the “hydrophobic effect?”

A

Water has a dipole moment, which results in a slight (+) and (-) charge on water. This allows for hydrogen bonding

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5
Q

How can one drive a reaction to the product side? What is this manipulation called?

A

Add reactant/remove products - Le Chatlier’s Principle (“Law of Mass Action”); also, add heat

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6
Q

The reaction of Glucose to Glucose-6-phosphate occurs by the enzyme hexokinase. What is the Delta-G prime for this reaction if there is 1 mole of glucose, and 1000 moles of G-6-P?

A

Delta G’ = -RT(ln[prod]/[react]) = -8.31(310)(ln[1000]/[1]]) = -2576.1xln([1000]/[1]]) = -17.8kJ/mol

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7
Q

The reaction of Fructose-6-P to Fructose-1,6-bisphosphate occurs by the enzyme phosphofructokinase. What is the Delta-G prime for this reaction if there is 100 mole of F-6-P, and 1 mole of F-1,6-BP?

A

Delta G’ = -RT(ln[prod]/[react]) = -8.31(310)ln([100]/[1]) = -11863.4 Jmol^-1/1000 = -11.9 kJ/mol

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8
Q

The reaction of Fructose-6-P to Fructose-1,6-bisphosphate occurs by the enzyme phosphofructokinase. What is the Delta-G prime for this reaction if there is 10 mole of F-6-P, and 1 mole of F-1,6-BP?

A

Delta G’ = -RT(ln[prod]/[react])

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9
Q

The reaction of Fructose-6-P to Fructose-1,6-bisphosphate occurs by the enzyme phosphofructokinase. What is the Delta-G prime for this reaction if there is 1 mole of F-6-P, and 1000 mole of F-1,6-BP?

A

Delta G’ = -RT(ln[prod]/[react])

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10
Q

What is the pH of a solution acetoacetic acid? The [A]=100 and [HA]=1 (pKa=3.58)

A

pH=pKa+log([A]/[HA] pH=3.58 + log[100]/[1] pH=3.58+2 pH=5.58

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11
Q

What is the pH of a solution acetoacetic acid? The [A]=1 and [HA]=1 (pKa=3.58)

A

pH=pKa+log([A]/[HA] pH=3.58+log([1]/[1]) pH=3.58+0 pH=3.58

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12
Q

What is the pH of a solution acetoacetic acid? The [A]=1 and [HA]=100 (pKa=3.58)

A

pH=pKa+log([A]/[HA] pH=3.58+log([1]/[100]) pH=3.58-2 pH=1.58

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13
Q

Energy can neither be created nor destroyed, only changed

A

First law of thermodynamics

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14
Q

The entropy of an isolated system not in equillibrium must increase

A

Second law of thermodynamics

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15
Q

First law of thermodynamics

A

Energy can neither be created nor destroyed, only changed

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16
Q

Second law of thermodynamics

A

The entropy of an isolated system not in equillibrium must increase

17
Q

Delta G = -(R)(T)ln(Keq)

A

Standard free-E* change equation

18
Q

Delta G=Delta G*‘+ln([Prod]/[React])

A

Gibbs Free E* equation

19
Q

Hydrophobic interactions, van der Waal’s, electrostatic interactions

A

Three types of non-covalent bonds

20
Q

Water has a dipole moment, which results in a slight (+) and (-) charge on water. This allows for hydrogen bonding

A

What produces the “hydrophobic effect?”

21
Q

Add reactant/remove products - Le Chatlier’s Principle (“Law of Mass Action”); also, add heat

A

How can one drive a reaction to the product side? What is this manipulation called?

22
Q

Delta G’ = -RT(ln[prod]/[react]) = -8.31(310)(ln[1000]/[1]]) = -2576.1xln([1000]/[1]]) = -17.8kJ/mol

A

The reaction of Glucose to Glucose-6-phosphate occurs by the enzyme hexokinase. What is the Delta-G prime for this reaction if there is 1 mole of glucose, and 1000 moles of G-6-P?

23
Q

Delta G’ = -RT(ln[prod]/[react]) = -8.31(310)ln([100]/[1]) = -11863.4 Jmol^-1/1000 = -11.9 kJ/mol

A

The reaction of Fructose-6-P to Fructose-1,6-bisphosphate occurs by the enzyme phosphofructokinase. What is the Delta-G prime for this reaction if there is 100 mole of F-6-P, and 1 mole of F-1,6-BP?

24
Q

Delta G’ = -RT(ln[prod]/[react])

A

The reaction of Fructose-6-P to Fructose-1,6-bisphosphate occurs by the enzyme phosphofructokinase. What is the Delta-G prime for this reaction if there is 10 mole of F-6-P, and 1 mole of F-1,6-BP?

25
Q

Delta G’ = -RT(ln[prod]/[react])

A

The reaction of Fructose-6-P to Fructose-1,6-bisphosphate occurs by the enzyme phosphofructokinase. What is the Delta-G prime for this reaction if there is 1 mole of F-6-P, and 1000 mole of F-1,6-BP?

26
Q

pH=pKa+log([A]/[HA] pH=3.58 + log[100]/[1] pH=3.58+2 pH=5.58

A

What is the pH of a solution acetoacetic acid? The [A]=100 and [HA]=1 (pKa=3.58)

27
Q

pH=pKa+log([A]/[HA] pH=3.58+log([1]/[1]) pH=3.58+0 pH=3.58

A

What is the pH of a solution acetoacetic acid? The [A]=1 and [HA]=1 (pKa=3.58)

28
Q

pH=pKa+log([A]/[HA] pH=3.58+log([1]/[100]) pH=3.58-2 pH=1.58

A

What is the pH of a solution acetoacetic acid? The [A]=1 and [HA]=100 (pKa=3.58)

29
Q

First law of thermodynamics

A

Energy can neither be created nor destroyed, only changed

30
Q

Second law of thermodynamics

A

The entropy of an isolated system not in equillibrium must increase

31
Q

Energy can neither be created nor destroyed, only changed

A

First law of thermodynamics

32
Q

The entropy of an isolated system not in equillibrium must increase

A

Second law of thermodynamics