Flashcards in Lecture 38 - GABA signalling Deck (17):
1
Draw the production/degradation of GABA.
Check your drawing
2
GABA is broken down into ____ and ____ by GABA-T.
succinic semi-aldehyde;
Glutamate
3
Succinic semiadehyde is broken down into ____ and _____. What is the enzyme used?
NADH, succinate;
SSADH-succinic semialdehyde deydrogenase
4
Glutamate is transformed into GABA with the release of ____. What enzyme is used?
CO2,
GAD (Glutamic acid decarboxylase)
5
The benzodiazepine receptor on GABA-R is located between what two domains?
alpha and gamma.
6
The GABA binding region is located between what two domains?
alpha and beta
7
The binding of GABA to the GABA site produces hyperpolarization of the neuron via ________.
a. chloride efflux
b. chloride influx
c. Na efflux
d. Na influx
B. chloride influx
8
More specificially, the GABA binding site is found on the (C-terminus/N-terminus) of the protein.
N-terminus
9
Between the final transmembrane regions of the protein, there is a _________.
large cytoplasmic loop
10
___ subunits combine to form 1 GABA-R
5
11
How many transmembrane passes are made by the GABA-R?
A. 3
B. 4
C. 5
D. 6
B. 4
12
Across all PLGICs, the (C-terminus/N-terminus) region is homologous.
N-terminus
13
What does PLGIC stand for?
Pentameric Ligand Gated Ion Channel
14
GABA-R that bind neurotransmitter only on post-synaptic dendrites are called what type of inhibition?
a. phasic
b. tonic
a. phasic
15
The transmembrane regions of the receptor are what 2* structure?
a. alpha-helix
b. beta-barrels
a. alpha helix
16
GABA-R that bind neurotransmitter on extra-synaptic dendrites are called what type of inhibition?
a. phasic
b. tonic
b. tonic (quiets the entire cell)
17