Lecture 38 - GABA signalling Flashcards Preview

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Flashcards in Lecture 38 - GABA signalling Deck (17):
1

Draw the production/degradation of GABA.

Check your drawing

2

GABA is broken down into ____ and ____ by GABA-T.

succinic semi-aldehyde;

Glutamate

3

Succinic semiadehyde is broken down into ____ and _____. What is the enzyme used?

NADH, succinate;

SSADH-succinic semialdehyde deydrogenase

4

Glutamate is transformed into GABA with the release of ____. What enzyme is used?

CO2,

GAD (Glutamic acid decarboxylase)

5

The benzodiazepine receptor on GABA-R is located between what two domains?

alpha and gamma.

6

The GABA binding region is located between what two domains?

alpha and beta

7

The binding of GABA to the GABA site produces hyperpolarization of the neuron via ________.

a. chloride efflux
b. chloride influx
c. Na efflux
d. Na influx

B. chloride influx

8

More specificially, the GABA binding site is found on the (C-terminus/N-terminus) of the protein.

N-terminus

9

Between the final transmembrane regions of the protein, there is a _________.

large cytoplasmic loop

10

___ subunits combine to form 1 GABA-R

5

11

How many transmembrane passes are made by the GABA-R?

A. 3
B. 4
C. 5
D. 6

B. 4

12

Across all PLGICs, the (C-terminus/N-terminus) region is homologous.

N-terminus

13

What does PLGIC stand for?

Pentameric Ligand Gated Ion Channel

14

GABA-R that bind neurotransmitter only on post-synaptic dendrites are called what type of inhibition?

a. phasic
b. tonic

a. phasic

15

The transmembrane regions of the receptor are what 2* structure?

a. alpha-helix
b. beta-barrels

a. alpha helix

16

GABA-R that bind neurotransmitter on extra-synaptic dendrites are called what type of inhibition?

a. phasic
b. tonic

b. tonic (quiets the entire cell)

17

What molecule anchors the GABA-R to the cytoskeleton?

A. microtubules
B. Na/K/ATPase pumps
C. Clathrin
D. Gephyrin

D. Gephyrin