Lecture 38 - GABA signalling Flashcards
(17 cards)
Draw the production/degradation of GABA.
Check your drawing
GABA is broken down into ____ and ____ by GABA-T.
succinic semi-aldehyde;
Glutamate
Succinic semiadehyde is broken down into ____ and _____. What is the enzyme used?
NADH, succinate;
SSADH-succinic semialdehyde deydrogenase
Glutamate is transformed into GABA with the release of ____. What enzyme is used?
CO2,
GAD (Glutamic acid decarboxylase)
The benzodiazepine receptor on GABA-R is located between what two domains?
alpha and gamma.
The GABA binding region is located between what two domains?
alpha and beta
The binding of GABA to the GABA site produces hyperpolarization of the neuron via ________.
a. chloride efflux
b. chloride influx
c. Na efflux
d. Na influx
B. chloride influx
More specificially, the GABA binding site is found on the (C-terminus/N-terminus) of the protein.
N-terminus
Between the final transmembrane regions of the protein, there is a _________.
large cytoplasmic loop
___ subunits combine to form 1 GABA-R
5
How many transmembrane passes are made by the GABA-R?
A. 3
B. 4
C. 5
D. 6
B. 4
Across all PLGICs, the (C-terminus/N-terminus) region is homologous.
N-terminus
What does PLGIC stand for?
Pentameric Ligand Gated Ion Channel
GABA-R that bind neurotransmitter only on post-synaptic dendrites are called what type of inhibition?
a. phasic
b. tonic
a. phasic
The transmembrane regions of the receptor are what 2* structure?
a. alpha-helix
b. beta-barrels
a. alpha helix
GABA-R that bind neurotransmitter on extra-synaptic dendrites are called what type of inhibition?
a. phasic
b. tonic
b. tonic (quiets the entire cell)
What molecule anchors the GABA-R to the cytoskeleton?
A. microtubules
B. Na/K/ATPase pumps
C. Clathrin
D. Gephyrin
D. Gephyrin
