Lecture 38 - GABA signalling Flashcards Preview

Biochemistry > Lecture 38 - GABA signalling > Flashcards

Flashcards in Lecture 38 - GABA signalling Deck (17)
Loading flashcards...
1
Q

Draw the production/degradation of GABA.

A

Check your drawing

2
Q

GABA is broken down into ____ and ____ by GABA-T.

A

succinic semi-aldehyde;

Glutamate

3
Q

Succinic semiadehyde is broken down into ____ and _____. What is the enzyme used?

A

NADH, succinate;

SSADH-succinic semialdehyde deydrogenase

4
Q

Glutamate is transformed into GABA with the release of ____. What enzyme is used?

A

CO2,

GAD (Glutamic acid decarboxylase)

5
Q

The benzodiazepine receptor on GABA-R is located between what two domains?

A

alpha and gamma.

6
Q

The GABA binding region is located between what two domains?

A

alpha and beta

7
Q

The binding of GABA to the GABA site produces hyperpolarization of the neuron via ________.

a. chloride efflux
b. chloride influx
c. Na efflux
d. Na influx

A

B. chloride influx

8
Q

More specificially, the GABA binding site is found on the (C-terminus/N-terminus) of the protein.

A

N-terminus

9
Q

Between the final transmembrane regions of the protein, there is a _________.

A

large cytoplasmic loop

10
Q

___ subunits combine to form 1 GABA-R

A

5

11
Q

How many transmembrane passes are made by the GABA-R?

A. 3
B. 4
C. 5
D. 6

A

B. 4

12
Q

Across all PLGICs, the (C-terminus/N-terminus) region is homologous.

A

N-terminus

13
Q

What does PLGIC stand for?

A

Pentameric Ligand Gated Ion Channel

14
Q

GABA-R that bind neurotransmitter only on post-synaptic dendrites are called what type of inhibition?

a. phasic
b. tonic

A

a. phasic

15
Q

The transmembrane regions of the receptor are what 2* structure?

a. alpha-helix
b. beta-barrels

A

a. alpha helix

16
Q

GABA-R that bind neurotransmitter on extra-synaptic dendrites are called what type of inhibition?

a. phasic
b. tonic

A

b. tonic (quiets the entire cell)

17
Q

What molecule anchors the GABA-R to the cytoskeleton?

A. microtubules
B. Na/K/ATPase pumps
C. Clathrin
D. Gephyrin

A

D. Gephyrin