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Flashcards in adrenal insufficiency Deck (20)
1

adrenal androgens are made in the ___ and ____

zona fasciculata and reticularis

2

are deficiencies in DHEA common?

no, b/c majority of androgens are made in testes and ovaries

3

renin is produced where?

justaglomerular cells of afferent arterioles

4

ACE is converted where?

endothelium of lung capillaries

5

ACTH is synthesized as part of larger precursor molec called?

POMC

6

what does POMC get cleaved into (3)

1. ACTH
2. lipotropin
3. melanocyte stimulating hormone

7

how to tx primary adrenal insufficiency (2)

1. fludrocortisone
2. hydrocortisone

8

most common cause of primary adrenal insufficiency in US

autoimmune destruction

9

most common cause of primary adrenal insufficiency in the world

TB

10

primary AI glands from autoimmune destruction are ____, and from TB are____

small, lymphocytic infiltration; large & calcified/granulomatous

11

normal adrenal response to cortosyn stimulation test

>18

12

tx of primary adrenal insufficiency

1. hydrocortisone 2x/day
2. fludrocortisone daily

13

in times of minor stress, what to do with dose of cortisol in PAI?

double dose

14

5 S's to tx adrenal crisis

1. salt (NS)
2. sugar (dextrose)
3. steroids
4. support
5. search for precipitating illness

15

primary adrenal insufficiency leads to loss of ______, whereas secondary adrenal insufficiency leads to loss of______

aldosterone, corticosteroids;
corticosteroids

16

transient secondary adrenal insufficiency is most commonly caused by

abrupt cessation of exogenous use of steroids

17

if dosing prednisone > ____for _____days, and it is stopped abruptly, is can cause secondary adrenal insufficiency

15; 14 days

18

dx of AI: cortisol under ____with stress; morning cortisol under _____

5; 3

19

how to differentiate primary and secondary AI?

ACTH level

20

tx of secdonary adrenal insufficiency

hydrocortisone