Flashcards in adrenal insufficiency Deck (20)
adrenal androgens are made in the ___ and ____
zona fasciculata and reticularis
are deficiencies in DHEA common?
no, b/c majority of androgens are made in testes and ovaries
renin is produced where?
justaglomerular cells of afferent arterioles
ACE is converted where?
endothelium of lung capillaries
ACTH is synthesized as part of larger precursor molec called?
what does POMC get cleaved into (3)
3. melanocyte stimulating hormone
how to tx primary adrenal insufficiency (2)
most common cause of primary adrenal insufficiency in US
most common cause of primary adrenal insufficiency in the world
primary AI glands from autoimmune destruction are ____, and from TB are____
small, lymphocytic infiltration; large & calcified/granulomatous
normal adrenal response to cortosyn stimulation test
tx of primary adrenal insufficiency
1. hydrocortisone 2x/day
2. fludrocortisone daily
in times of minor stress, what to do with dose of cortisol in PAI?
5 S's to tx adrenal crisis
1. salt (NS)
2. sugar (dextrose)
5. search for precipitating illness
primary adrenal insufficiency leads to loss of ______, whereas secondary adrenal insufficiency leads to loss of______
transient secondary adrenal insufficiency is most commonly caused by
abrupt cessation of exogenous use of steroids
if dosing prednisone > ____for _____days, and it is stopped abruptly, is can cause secondary adrenal insufficiency
15; 14 days
dx of AI: cortisol under ____with stress; morning cortisol under _____
how to differentiate primary and secondary AI?