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Flashcards in hypothyroidism Deck (18)
1

hyperthyroidism following administration of iodine or iodide

Jod-Basedow phenomenon

2

reduction in thyroid hormone levels caused by ingestion of a large amount of iodine due to autoregulatory phenomenon that inhibits organification in the thyroid gland

Wolff–Chaikoff effect

3

does T4 or T3 have a longer half life?

T4

4

T4 has a half life of ____, T3 is ____

7 days; 1 day

5

what is the primary binding protein of T3/T4?

thyroid binding globulin

6

factors that incr TBG? (2)

1. estrogen (pregnancy, BCP)
2. congenital

7

factors that decr TBG (2)

1. systemic illness
2. glucocorticoids

8

best test of thyroid fxn

TSH

9

thyroid dysfxn stemming from the thryroid

primary

10

thyroid dysfxn stemming from the pit or the hypothalamus

secondary

11

if you suspect secondary hypothyrodism, is the TSH reliable?

no, it will be constantly low

12

what is the most common cause of hypothyroidism in iodine sufficient areas?

hashimotos thyroiditis

13

how to tx hypothyroidism

levothyroxine (T4)

14

when is tx of hypothyroidism indicated?

TSH >10

15

when to recheck labs after starting levothyroxine?

1. 6 weeks later
2. switch meds
3. starts BCP
4. pregnant

16

what happens to thyroid hormone during pregnancy?

needs for thyroid hormone increase

17

mental status changes, hypothermia, hyperglycemia, respiratory failure, hypotension, bradycardia

myxedema coma

18

what to measure for secondary hypothyroidism?

free T4