Pancreas/adrenal Histology Flashcards Preview

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Flashcards in Pancreas/adrenal Histology Deck (33)
1

pancreatic islets are derived from____

endoderm

2

what provides the supporting framework for pancreatic islets?

reticular fibers

3

pancreatic islets are accompanied by ____and ____

capillaries and ANS fibers

4

70% of cells in islets are?

beta cells

5

where are beta cells located?

scattered throughout, but concentrated in center

6

tumor that can drive down blood glu levels

insulinoma

7

where are alpha cells located?

periphery of pancreas

8

what do alpha cells secrete?

glucagon

9

GLUT2 transporter is insulin______

independent

10

_____may be used to promote insulin secretion in type II diabetics

sulfonylurea receptor inhibitors

11

name the sulfonylurea receptor inhibitors

1. gliclazide
2. glimepiride

12

role of GLUT2 transport protein

to transport glu into cell in order to stimulate insulin secretion

13

GLUT4 transporter is insulin_____

dependent

14

adrenal gland outer cortex is derived from_____, inner medulla derived from_____

mesoderm; neural crest cells

15

what is req'd for differentiation of precursor cells into chromaffin cells? (2)

cortisol
NGF

16

Superior suprarenal artery branches from what parent artery?

inferior phrenic

17

middle suprarenal artery branches from what parent artery?

aorta

18

inferior suprarenal artery branches from what parent artery?

renal

19

subscapular plexus divides into (2)

1. cortical arteries
2. medullary arteries

20

in the zona glomerulosa, the secretory prodcts are ____

aldosterone

21

in the zona fasciculata, the secretory products are

cortisol

22

in the zona reticularis, the secretory products are

sex hormones (androgens)

23

what type of cells are absent in the zona fasciculata?

secretory vesicles

24

ACTH has an effect on cells of which compartments (2

1. zona fasciculata
2. zona reticularis

25

what is the zona glomerulosa under the control of?

1. Angiotensin
2. Potassium

26

chromaffin cells are ____sympathetic neurons, innervated by ____fibers from _____

postganglionic; preganglionic; T8-L1

27

what enzymes converts NE-->epi?

phenylethanolamine N methyltransferase

28

phenylethanolamine N methyltransferase requires the presence of?

cortisol

29

where does the synthesis or Epi and NE occur?

cytosol of chromaffin

30

besides the adrenal glands, chromaffin tissue can also be found where?

organ of zuckerkandl

31

where is the organ of zuckerkandl

at the bifurcation of the aorta and the IMA

32

a tumor of teh organ of zuckerkandl would be expected to incr the output of?

NE

33

congenital adrenal hyperplasia results in?

ambiguous genitalia