Flashcards in Type 1 DM Deck (29)
what drugs can induce diabetes?
T1DM with autoimmune etiology
T1DM with no evidence of autoimmunity
which chromosone has major susceptibility genes for T1DM
on HLA region of chrom 6
which haplotypes make one more susceptible for DM1
is genetic risk higher for kids who has affected mother or father?
what mediates the immune response in Type 1 DM?
inappropriate adaptive immune response that targets beta cells
does type 1A or 1B have an HLA association?
what specifically mediates destruction of the beta cells
80% of ppl are positive for what Ab at time of dx?
glutamic acid decarboxylase Ab (GAD65)
is risk of Type1 DM proportional to number of Ab present?
perinatal factors related to incr risk of Type 1 DM (5)
1. maternal age >25
4. neonatal respiratory distress
what may be protective against type 1 DM?
breastfeeding, vitamin D, exposure to immune-mediated diseases in childhood
what is the bimodal distribution of T1DM?
age 4-6, 10-14
what is needed for Dx of T1DM (3)
1. formal OGTT
2. Ab may be present
3. low C-peptide
how does DKA present?
dehydration, acidosis, low BP, orthostasis, tachycardia, acetone smell, decr body temp
tx of DKA (3)
1. aggressive volume resuscitation
2. correct hyperglycemia with insulin
3. replete elecrolytes
tx goals of diabetes (4)
2. normal A1c
3. normal growth
4. tx cardiac risk factors
which meds are used to meet basal needs (2)
what sort of insulin to use for meal or stress needs
what is the total insulin requiremnt in T1DM
0.6 units/ kg bodyweight
what is basal insulin requirement?
0.2-0.3 U/Kg body weight
what percentage of daily insulin needs to be given as basal insulin?
what is a continous subcut insulin infusion
what is the best way to minic basal and bolus insulin
what sort of insulin can be used in a pump?
shorter/rapid acting insulin
what mimics amylin, slows GI transit, decr glucagon, decr appetite
use of pramlitide?
use in addition to insulin to help with post meal control in T1DM