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Flashcards in Type 1 DM Deck (29)
1

what drugs can induce diabetes?

glucocorticoids
atypical antipsychotics

2

T1DM with autoimmune etiology

Type 1a

3

T1DM with no evidence of autoimmunity

Type 1b

4

which chromosone has major susceptibility genes for T1DM

on HLA region of chrom 6

5

which haplotypes make one more susceptible for DM1

HLA-DR3
DQB
DR4

6

is genetic risk higher for kids who has affected mother or father?

affected father

7

what mediates the immune response in Type 1 DM?

inappropriate adaptive immune response that targets beta cells

8

does type 1A or 1B have an HLA association?

type 1A

9

what specifically mediates destruction of the beta cells

T cells

10

80% of ppl are positive for what Ab at time of dx?

glutamic acid decarboxylase Ab (GAD65)

11

is risk of Type1 DM proportional to number of Ab present?

yes

12

perinatal factors related to incr risk of Type 1 DM (5)

1. maternal age >25
2. smoking
3. preeclampsia
4. neonatal respiratory distress
5. jaundice

13

what may be protective against type 1 DM?

breastfeeding, vitamin D, exposure to immune-mediated diseases in childhood

14

what is the bimodal distribution of T1DM?

age 4-6, 10-14

15

what is needed for Dx of T1DM (3)

1. formal OGTT
2. Ab may be present
3. low C-peptide

16

how does DKA present?

dehydration, acidosis, low BP, orthostasis, tachycardia, acetone smell, decr body temp

17

tx of DKA (3)

1. aggressive volume resuscitation
2. correct hyperglycemia with insulin
3. replete elecrolytes

18

tx goals of diabetes (4)

1.normoglycemia
2. normal A1c
3. normal growth
4. tx cardiac risk factors

19

which meds are used to meet basal needs (2)

1. glargine
2. detemir

20

what sort of insulin to use for meal or stress needs

bolus/rapid insulin

21

what is the total insulin requiremnt in T1DM

0.6 units/ kg bodyweight

22

what is basal insulin requirement?

0.2-0.3 U/Kg body weight

23

what percentage of daily insulin needs to be given as basal insulin?

50%

24

what is a continous subcut insulin infusion

pump

25

what is the best way to minic basal and bolus insulin

pump

26

what sort of insulin can be used in a pump?

shorter/rapid acting insulin

27

what mimics amylin, slows GI transit, decr glucagon, decr appetite

pramlitide

28

use of pramlitide?

use in addition to insulin to help with post meal control in T1DM

29

what allows you to monitor glu every few min?

CGMS