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Flashcards in hypopituitarism Deck (31)
1

a majority of cases of hypopituitarism are due to?

pituitary disease >hypothalamic disease > idiopathic

2

post pregnancy w/ post-partum hemorrhage, inability to lactate or return to normal menses, lethargy, anorexia, weight loss

sheehan's syndrome

3

when a pituitary adenoma hemorrhages into itselt

pituitary apoplexy

4

sudden onset of excruciating pain, diplopia due to pressure on oculomotor nerves

pituitary apoplexy

5

lymphocytic invasion followed by destruction of pit cells occuring late pregnancy or post-partum

lymphocytic hypophysitis

6

is primary or secondary empty sella syndrome more commonly assc'd with hypopituitarism?

secondary

7

low cortisol, low ACTH, does not result in aldosterone deficiency

secondary adrenal insufficiency

8

does primary or secondary Adrenal insufficiency result in hyperpigmentation?

primary

9

what is a deficient morning cortisol reading?

under 3

10

what is a normal morning cortisol?

>18

11

tx for ACTH deficiency

hydrocortisone 15-30 mg daily

12

secondary hypothyroidism presents with ___T4 and ____TSH

low T4, low TSH

13

tx for TSH deficiency

L-thyroxine

14

what is unneccesary to measure in secondary hypothyroidism

TSH (it will always be low)

15

what to measure if woman presents with abnormal menstrual cycles

estradiol, LH, FSH

16

estradiol, LH, FSH are expected to be _____ in gonadotropin deficiency

low

17

what is the most common measurement of GH deficiency?

IGF-1

18

likelihood of deficiencies in panhypopituitarism

GH > LH/FSH > TSH> ACTH

19

how to tx GH deficiency

recombinant human growth hormone

20

what are the 2 things that stimulate vasopressin release?

1. increase in plasma osmolality
2. decr in plasma volume

21

where are the V1 receptors?

vasculature

22

where are the V2 receptors?

renal tubules

23

stimulation of V1 receptors?

vasoconstriction

24

stimulation of V2 receptors ____permeability of renal tubules

increases

25

when to admin desmopressin

if central diabetes insipidis & if urine volumers >4 L /day

26

desmopressin/ddAVP is specific to what type of receptor?

V2

27

serum prolactin under 200 = prolactinoma of what size?

under 1 cm

28

serum prolactin 200-1000 = prolactinoma of what size?

1-2 cm

29

serum prolactin >1000 = prolactinoma of what size?

>2 cm

30

prolactin levels under 100 are caused by stalk compression or prolactinoma?

stalk compression

31

in prolactinomas, prolactin levels are _____

proportional to size of tumor